Bharat Book Bureau

This market research report analyzes the diabetes care devices market in Brazil, Russia, India, and China (BRIC) over the period 2009-2014. The report categorizes the overall market for diabetes care devices into the submarkets for insulin pumps, self-monitoring blood glucose systems, and continuous glucose monitoring systems.

The diabetes care devices market in BRIC nations was approximately $257.55 million in 2009 and is expected to grow a CAGR of 17.24% from 2009 to 2014, driven mainly by the increasing incidence of diabetes and the corresponding rise in governmental support for diabetes care across BRIC nations. China was the largest diabetes care market in 2009 with approximately $135.65 million, followed for Russia, India, and Brazil.

Market estimates and forecast

The report provides in-depth market estimates and forecast for diabetes care devices in Brazil, Russia, India and China. It includes estimates and forecast for insulin pumps, self monitoring blood glucose (SMBG) and continuous glucose monitoring (CGM) in each of the four geographies of Brazil, Russia, India and China.

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15 pages of high level analysis including benchmarking strategies, best practices and the market’s cash cows (BCG matrix). We conduct detailed market positioning, product positioning and competitive positioning. Entry strategies, gaps and opportunities are identified for all the stakeholders.

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The total arthroscopic devices market was valued at over $800 million in 2009.

The total arthroscopic devices market includes:

large and small joint arthroscopes,
hand instruments,
fluid management disposables,
power instruments and shaver blades,
radiofrequency (RF) probes and
drill guides

This report covers market trends and analysis, as well as a description of the competitive activities of the companies involved in each segment. In addition, unit volume information is included regarding cannulas. This market is closely associated with the market for soft tissue repair devices, which is covered in the companion report, U.S. Market for Orthopedic Soft Tissue and Sports Medicine.

This report provides a comprehensive and detailed analysis of market revenues by device type, market forecasts through 2016, unit sales, average selling prices, market drivers and limiters and a detailed competitive analysis, including manufacturer market shares and product portfolios.

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This report analyzes the global healthcare equipment market in terms of market size, key drivers and resistors, trends and competitive positioning. It includes profiles of the top ten companies in the industry along with 5-year financial analysis and in-depth SWOT analysis.

Scope

* Performance of the global healthcare equipment market on the basis of sales, volume and respective growth patterns over the past five years
* Obtain descriptive profiles of the top ten leading players including strategic initiatives undertaken in the last 12 months
* Analysis of the Strengths, Weaknesses, Opportunities and Threats of the top 10 healthcare equipment companies along with business overview and financials
* Benchmark the performance of the top 10 players for the past five years; includes revenue comparison, profitability analysis, industry-specific ratios

Highlights

The global health care equipment market generated total revenues of $148.4 billion in 2008, representing a CAGR of 5% for the period spanning 200408.

Ophthalmic equipment sales proved the most lucrative for the global health care equipment market in 2008, generating total revenues of $47.2 billion, equivalent to 31.82% of the market’’s overall value.

The performance of the market is forecast to accelerate, with an anticipated CAGR of 6.2% for the five-year period 200813, which is expected to drive the market to a value of $200.8 billion by the end of 2013.

Reasons to Purchase

* Save time, money and resources on analyzing the top 10 healthcare equipment companies using this report
* Analyze the global healthcare equipment market with key industry metrics including market value, market volume, and growth forecasts
* Assess the intensity of competition based on the 5-forces model including degree of rivalry, substitutes, new entrants, buyer power and supplier power

Table of Contents:

Table of Contents 2
FIGURES 3
Tables 4
Executive Summary 5
Industry analysis 5
Industry definition 5
Research highlights 5
Market Value 6
Market Forecast 7
Market Segmentation-Product 8
Market Segmentation-Geography 9
Five Forces Analysis 10
Summary 10
Buyer power 11
Supplier power 12
New entrants 13
Substitutes 15
Rivalry 16
Top 10 Companies Landscape 17
Overview 17
Johnson & Johnson 18
GE Healthcare 18
Siemens Healthcare 18
Medtronic 18
Baxter International 19
Philips Healthcare 19
Boston Scientific 19
Becton, Dickinson and Company 19
Stryker 19
Alcon 19
Revenue analysis 20
Financial performance analysis 22
Operating profit analysis 23
Net profit analysis 23
Ratio analysis 24
Company Reports 27
Johnson & Johnson 27
Company overview 27
Business description 27
SWOT analysis 28
Strengths 28
Weaknesses 28
Opportunities 29
Threats 30
Recent developments 30
GE Healthcare 32
Company overview 32
Business description 32
SWOT analysis 32
Strengths 32
Weaknesses 33
Opportunities 33
Threats 34
Recent developments 35
Siemens Healthcare 37
Company overview 37
Business description 37
SWOT analysis 38
Strengths 38
Weaknesses 39
Opportunities 39
Threats 40
Recent developments 40
Medtronic 41
Company overview 41
Business description 41
SWOT analysis 42
Strengths 42
Weaknesses 43
Opportunities 43
Threats 44
Recent developments 45
Baxter International 47
Company overview 47
Business description 47
SWOT analysis 47
Strengths 47
Weaknesses 49
Opportunities 49
Threats 50
Recent developments 51
Philips Healthcare 52
Company overview 52
Business description 52
SWOT analysis 53
Strengths 53
Weaknesses 53
Opportunities 54
Threats 55
Recent developments 55
Boston Scientific 57
Company overview 57
Business description 57
SWOT analysis 57
Strengths 57
Weaknesses 58
Opportunities 58
Threats 59
Recent developments 60
Becton, Dickinson and Company 62
Company overview 62
Business description 62
SWOT analysis 63
Strengths 63
Weaknesses 64
Opportunities 64
Threats 65
Recent developments 66
Stryker 68
Company overview 68
Business description 68
SWOT analysis 69
Strengths 69
Weaknesses 70
Opportunities 70
Threats 71
Recent developments 71
Alcon 72
Company overview 72
Business description 72
SWOT analysis 73
Strengths 73
Weaknesses 74
Opportunities 75
Threats 76
Recent developments 77
Financial Analysis 78
Johnson & Johnson 78
GE Healthcare 81
Siemens Healthcare 82
Medtronic 83
Baxter International 86
Philips Healthcare 89
Boston Scientific 90
Becton, Dickinson and Company 94
Stryker 97
Alcon 100
APPENDIX 104

List of Tables
Table 1: Global health care equipment market, $ billion, 2004-08 6
Table 2: Global health care equipment market forecast, $ billion, 2008-13 7
Table 3: Global health care equipment market segmentation-product, % share 2008 8
Table 4: Global health care equipment market segmentation-geography, % share 2008 9
Table 5: Revenues of global top 10 health care equipment companies, $ million, FY2008 17
Table 6: Revenue growth of global top 10 health care equipment companies, 2006-08 20
Table 7: Key financials of global top 10 health care equipment companies, FY2008 22
Table 8: Key industry specific ratios 25
Table 9: Johnson & Johnson-Financial and operational highlights, 2004-08 ($ million) 78
Table 10: Johnson & Johnson-Key industry specific ratios, 2004-08 80
Table 11: Medtronic-Financial and operational highlights, 2004-08 ($ million) 83
Table 12: Medtronic-Key industry specific ratios, 2004-08 85
Table 13: Baxter International-Financial and operational highlights, 2004-08 ($ million) 86
Table 14: Baxter International-Key industry specific ratios, 2004-08 88
Table 15: Boston Scientific-Financial and operational highlights, 2004-08 ($ million) 90
Table 16: Boston Scientific-Key industry specific ratios, 2004-08 93
Table 17: Becton, Dickinson and Company-Financial and operational highlights, 2004-08 ($ million) 94
Table 18: Becton, Dickinson and Company-Key industry specific ratios, 2004-08 96
Table 19: Stryker-Financial and operational highlights, 2004-08 ($ million) 97
Table 20: Stryker-Key industry specific ratios, 2004-08 99
Table 21: Alcon-Financial and operational highlights, 2004-08 ($ million) 100
Table 22: Alcon-Key industry specific ratios, 2004-08 102

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This report details the complete range of products and technologies in spine surgery, including the surgical management of spine disorders, diseases and trauma, with treatments including use of grafts, demineralized bone, fusion, stabilization, disc replacement, nucleus replacement, vertebroplasty, kyphoplasty, imaging, minimally invasive surgical technologies, energy-based therapies and biologics. The report details current clinical and technology developments in the huge and rapidly growing spine surgery technologies worldwide market, with data on products in development and on the market; market size and forecast; competitor market shares; competitor profiles; and market opportunity.

This report is a detailed market and technology assessment and forecast of the products and technologies in the management of diseases and disorders of the spine. The report describes diseases and disorders of the spine, encompassing congenital disorders, inflammatory and infectious diseases; degenerative diseases; herniations, stenoses, myelopathies and other “mechanical” disorders of the spine; spinal trauma; tumors of the spine; and others. The report characterizes the patient populations, their current clinical management, and trends in clinical management as new techniques and technologies are expected to be developed and emerge. The report details the currently available products and technologies, and manufacturer offerings. The report details products and technologies under development and markets for each in spine surgery. The report provides a current and forecast assessment of the worldwide markets for these technologies, with geographic segmentation by U.S. & Canada, European Union (detailing France, United Kingdom, Germany, Italy and Spain), Japan and Rest of World. The report provides emphasis on the market impact of new technologies through the coming decade, profiling nearly 100 active companies in this industry, with comprehensive detail on key companies, providing data on their current products, current market position and products under development.

Table of Contents:

Executive Summary
Non-fusion products
Disc arthroplasty (total disc replacement)
Nuclear arthroplasty
European Union
Asia-Pacific
Rest of World
Selected company-related events
Medtronic
LDR Spine
Synthes Spine
Disc Motion Technologies
Spine Structure
Products and technologies
CMS, carriers reverse decision on artificial discs
Cost effectiveness

Section 1:          The Spine: Structure, Disorders, Treatment
1.1         Overview: Spine Structure
1.2         Diseases and disorders of the spine
1.2.1             Congenital Disorders
1.2.2             Inflammatory and Infectious Diseases of the Spine
1.2.3             Degenerative Diseases of the Spine
1.2.4             Mechanical Disorders of the Spine
1.2.5             Spinal Trauma
1.2.6             Tumors of the Spine
1.3         Spine management
1.3.1             Clinical: the SPORT Study
1.3.2             Diagnostic studies
1.3.3             Surgical procedures of the spine
1.3.4             Minimally Invasive Procedures
1.3.5             Minimally Invasive Bone Grafting Procedures
1.3.6             Acupuncture for treatment of chronic low back pain

Section 2:          Products and Technologies
2.1         Bone grafts and bone graft substitutes
2.2         Demineralized bone matrix (DBM)
2.2.1             Particle based DBM
2.2.2             Biomimetic matrix bone substitute
2.2.3             Bone morphogenic proteins (BMPs)
2.3         Spinal fusion and fixation products and technologies
2.3.1             Spine surgery instrumentation
2.3.2             Cervical fusion devices
2.3.3             Interbody fusion devices
2.3.4             Posterior dynamic stabilization systems
2.4         Non-fusion products and technologies
2.4.1             Disc arthroplasty
2.4.2             Nuclear arthroplasty and nuclear disc prostheses
2.4.3             Facet repair and replacement
2.5         Vertebroplasty and kyphoplasty
2.5.1             Vertebral compression fracture treatment technologies
2.6         Advances in spinal image-guided surgery
2.6.1             Medtronic’s StealthStation
2.6.2             GE Healthcare’s Fluoro-Spine
2.6.3             Elekta’s Axesse system
2.6.4             Zimmer’s ORTHOsoft Navitrack® FluoroSpine® System
2.7         Products and technologies for minimally invasive spinal surgery
2.7.1             ArthroCare’s spineWand
2.7.2             Medtronic’s MAST™ portfolio
2.7.3             NuVasive’s Maximum Access Surgery (MAS)
2.7.4             Abbott Spine’s Harmony Retractor
2.7.5             Globus transforaminal TDR device
2.8         Energy-based therapies
2.8.1             Bone growth stimulators
2.8.2             Intradiscal Electrothermal Therapy (IDET)
2.9         Biologics

Section 3:          Market Size, Forecast and Competitor Shares
3.1         Global market size, forecast and competitor shares
3.2         USA & Canada
3.2.1             Bone grafts and bone graft substitutes
3.2.2             Spinal fusion and fixation products
3.2.3             Non-fusion products
3.2.4             Vertebroplasty and Kyphoplasty
3.2.5             Interspinous process spacers (ISP)
3.2.6             Computer assisted image guided surgery products
3.3         European Union
3.3.1             United Kingdom
3.3.2             France
3.3.3             Germany
3.3.4             Italy
3.3.5             Spinal fusion and fixation products
3.3.6             Non-fusion products
3.3.7             Total disc replacement
3.3.8             Nucleus replacement
3.3.9             Interspinous process spacers (ISPs)
3.3.10           Kyphoplasty
3.3.11           Image Guided Surgery Products Market
3.4         Asia-Pacific
3.4.1             Spinal fusion and fixation products
3.4.2             Non-fusion products
3.4.3             Image guided surgery products
3.5         Rest of World

Section 4:          Regulatory, Cost and Reimbursement Issues
4.1         Regulatory Issues Associated with Spine Treatments, Materials and Methods
4.1.1             Regulatory issues regarding off-label usage
4.1.2             Changes to European Device Safety Regulations
4.1.3             NICE and dynamic stabilization procedures
4.2         Reimbursement Developments
4.2.1             CMS, carriers reverse decision on artificial discs
4.2.2             CMS reverses stand on two spinal fusion procedures
4.2.3             ArthroCare and DiscoCare
4.2.4             Bone growth factor reimbursement issues
4.2.5             CMS investigates Thermal Intradiscal Therapy
4.2.6             CMS announces new ICD-9-CM spinal procedure codes
4.2.7             Wellmark and energy-based treatments
4.3         Cost effectiveness

Section 5:          Company Profiles
5.1         Abbott Spine
5.2         AlloSource
5.3         Alphatec Holdings, Inc.
5.4         Altiva Corporation
5.5         Anulex Technologies, Inc.
5.6         ApaTech
5.7         Applied Spine Technologies
5.8         ArthroCare Corporation
5.9         A-Spine Holding Group Corporation
5.10       Axial Biotech
5.11       AxioMed Spine Corporation
5.12       B. Braun/Aesculap, Inc.
5.13       BioAssets Development Corporation
5.14       Biomet
5.15       Biorthex, Inc.
5.16       Blackstone Medical, Inc
5.17       BrainLAB
5.18       Cardinal Health
5.19       Cervitech
5.20       Changzhou Kanghui
5.21       Co.Don AG
5.22       CoLigne AG
5.23       Cook Group
5.24       CoreSpine Technologies LLC
5.25       Corin Group
5.26       Cortek, Inc
5.27       Cryolife, Inc.
5.28       Cyberkinetics Neurotechnology Systems
5.29       Cytori Therapeutics
5.30       DePuy Spine/J&J
5.31       Disc Dynamics
5.32       Disc Motion Technologies
5.33       Encore Medical Corporation / DJO Surgical (ReAble Therapeutics)
5.34       Facet Solutions
5.35       Fixano (Small Bone Innovations)
5.36       GE Healthcare
5.37       Gentis, Inc
5.38       Globus Medical
5.39       GMReis
5.40       HydroCision
5.41       [Innovative Spinal Technologies — ceased operations January 2009]
5.42       Integra LifeSciences
5.43       Integra Radionics
5.44       Interpore Cross
5.45       Interventional Spine
5.46       Invibio
5.47       LDR Holding Corporation
5.48       LifeNet Health, Inc.
5.49       Mazor Surgical Technologies Ltd
5.50       Medtronic, Inc
5.51       Medtronic Sofamor Danek
5.52       Medtronic Surgical Navigation
5.53       Mekanika, Inc.
5.54       Merck & Co., Inc.
5.55       MiMedx
5.56       Misonix
5.57       MTF (Musculoskeletal Transplant Foundation)
5.58       NPS Pharmaceuticals
5.59       N Spine, Inc. (Synthes)
5.60       NuVasive, Inc.
5.61       Ortho Development Corporation
5.62       Orthofix International, N.V.
5.63       OrthoVita
5.64       Osiris Therapeutics
5.65       Osteotech, Inc.
5.66       Ortosintese
5.67       Paradigm Spine, LLC
5.68       Pitkar
5.69       Praxim
5.70       Ranier Technology Limited
5.71       Raymedica, Inc.
5.72       Regeneration Technologies, Inc
5.73       Scient’X
5.74       SeaSpine, Inc.
5.75       Sharma Surgical
5.76       Small Bone Innovations, LLC
5.77       Smart Disc
5.78       Smith & Nephew
5.79       SpinalMotion
5.80       SpineMedica Corporation
5.81       Spineology
5.82       SpineOvations
5.83       SpineVision Inc
5.84       Spine Wave, Inc.
5.85       Stryker Corporation
5.86       Stryker Instruments
5.87       Stryker Spine
5.88       Synthes Spine Solutions
5.89       Theken Spine
5.90       TranS1, Inc.
5.91       Trimedyne, Inc.
5.92       Ulrich Medical GmbH
5.93       Valleylab
5.94       Vertebron Inc.
5.95       Waston Medical
5.96       Wright Medical Technology
5.97       X-spine Systems, Inc.
5.98       Zimmer Spine
Appendix:  Company Directory

List of Exhibits

Exhibit ES-1: Total Global Spine Surgery Market, 2008-2017
Exhibit ES-2: Total Global Spine Surgery Market, 2008-2017
Exhibit ES-3: Global Spine Surgery Market by Segment, in USD Terms
Exhibit ES-4: Global Spine Surgery Market by Percentage and Segments, 2008
Exhibit ES-5: Major Spine Market Segments, 2008-2017
Exhibit ES-6: Key Factors Driving Growth in the Global Spine Surgery Market
Exhibit ES-7: Global Spine Surgery Market Shares, 2008
Exhibit ES-8: US & Canadian Market for Spine Surgery Devices
Exhibit ES-9: US Company Market Shares for Spine Surgery Devices, 2008
Exhibit ES-10: Total Global Spine Surgery Market, by Region, 2008
Exhibit ES-11: Total EU Spine Surgery Market, 2008-2017
Exhibit ES-12: Total EU Spine Surgery Market, 2008-2017
Exhibit ES-13: EU Spine Surgery Market Shares, 2008
Exhibit ES-14: Asia-Pacific: Total Spine Surgery Market, 2008-2017
Exhibit ES-15: Asia-Pacific: Total Spine Surgery Market, 2008-2017
Exhibit ES-16: Asia-Pacific: Spine Surgery Market Shares, 2008
Exhibit ES-17: Rest of World Spine Surgery Market Shares, 2008
Exhibit ES-18: ROW, Spine Surgery Markets, 2008-2017
Exhibit ES-19: Lateral and Posterior Views of the Spine
Exhibit ES-20: Human Spine Structure Showing Vertebrae, Intervertebral Discs, and Spinal Cord
Exhibit ES-21: US Census figures and projections, ages 65 and up, 1900-2050.
Exhibit ES-22: Number & Percentage of U.S. Population over Age 65, 1910–2050
Exhibit ES-23: Mechanical Disorders of the Spine
Exhibit ES-24: Start-up companies and areas of interest
Exhibit ES-25: CPT spinal fusion codes now allowed by CMS
Exhibit ES-26: Summary of CMS Medicare cost data

Exhibit 1-1: Lateral and Posterior Views of the Spine
Exhibit 1-2: Human Spine Structure Showing Vertebrae, Intervertebral Discs, and Spinal Cord
Exhibit 1-3: Components of the Human Spine
Exhibit 1-4: US Census figures and projections, ages 65 and up, 1900-2050.
Exhibit 1-5: Number & Percentage of U.S. Population over Age 65, 1910–2050
Exhibit 1-6: Congenital Disorders of the Spine
Exhibit 1-7: Inflammatory and Infectious Diseases of the Spine
Exhibit 1-8: Degenerative Diseases of the Spine
Exhibit 1-9: Estimated Annual Number of Fractures Due to Osteoporosis in the U.S. (Total: Over 1.5 Million)
Exhibit 1-10: Mechanical Disorders of the Spine
Exhibit 1-11: Location, Effects, and Incidence of Major Lumbar Disc Herniations
Exhibit 1-12: Clinical Features—Radiculopathy by Spinal Level
Exhibit 1-13: Causes of Trauma to Spinal Regions
Exhibit 1-14: Tumors of the Spine
Exhibit 1-15: Traditional (“Open”) Spinal Procedures
Exhibit 1-16: Estimated Number of Spinal Fusion Procedures Performed in the U.S., 2005–2015
Exhibit 1-17: Minimally Invasive Spinal Procedures

Exhibit 2-1: Spinal Allografts: Vendors and Products
Exhibit 2-2: Hydroxyapatite Bone Substitutes: Vendors, Products
Exhibit 2-3: Bone growth stimulatory proteins, peptides and devices
Exhibit 2-4: Fusion instrumentation companies
Exhibit 2-5: Developers of Interspinous Process Spacers
Exhibit 2-6: Developers of Total Disc Replacements
Exhibit 2-7: Artificial Cervical Discs Currently in US Clinical Trials
Exhibit 2-8: Artificial Cervical Discs Currently Available in the EU
Exhibit 2-9: Total disc replacement devices
Exhibit 2-10: Developers of Prosthetic Disc Nuclei
Exhibit 2-11: Nucleus replacement implants
Exhibit 2-12: Current nucleus arthroplasty motion preservation IDE pilot studies
Exhibit 2-13: Bone growth stimulatory proteins, peptides and devices
Exhibit 2-14: Cellular therapies: manufacturers and product
Exhibit 2-15: Other start-up companies and areas of interest

Exhibit 3-1: Total Global Spine Surgery Market, 2008-2017
Exhibit 3-2: Total Global Spine Surgery Market, 2008-2017
Exhibit 3-3: Global Spine Surgery Market by Segment, in USD Terms
Exhibit 3-4: Global Spine Surgery Market by Percentage and Segments, 2008
Exhibit 3-5: Key Factors Driving Growth in the Global Spine Surgery Market
Exhibit 3-6: Major Spine Market Segments, 2008-2017
Exhibit 3-7: Global Spine Surgery Market Shares, 2008
Exhibit 3-8: US & Canadian Market for Spine Surgery Devices
Exhibit 3-9: US & Canadian Market for Spine Surgery Devices
Exhibit 3-10: US Company Market Shares for Spine Surgery Devices, 2008
Exhibit 3-11: Usage of Bone Grafts and Bone Graft Substitutes in Spinal Fusion Procedures (excluding BMPs)
Exhibit 3-12: US Market for Bone Graft Substitutes
Exhibit 3-13: US Market for Spine-Related Orthobiologics, 2008-2017
Exhibit 3-14: US & Canadian Market for Spinal Fusion and Fixation Devices
Exhibit 3-14B:  US & Canadian Spinal Fusion Procedures by Segment (Cervical, Lumbar, Thoracic), 2008-2017
Exhibit 3-15: Number of Spinal Fusions
Exhibit 3-16: US & Canadian Market for Spinal Fusion and Fixation Devices
Exhibit 3-17: US Market Shares, Spinal Fusion and Fixation Devices, 2008
Exhibit 3-18: US Market Shares, Spinal Fusion and Fixation Devices, 2008
Exhibit 3-19 Total US Non-Fusion Device Market
Exhibit 3-20: Total US Non-Fusion Device Market
Exhibit 3-21: US Annulus Repair Market, 2009-2015
Exhibit 3-22: US Annulus Repair Market, 2009-2015
Exhibit 3-23: Total Market for Disc Arthroplasty (Cervical Plus Thoracolumbar)
Exhibit 3-24: US Market for Cervical Disc Replacement
Exhibit 3-25: US Market for Cervical Disc Replacement
Exhibit 3-26: US Market for Thoracolumbar Disc Replacement
Exhibit 3-27: US Market for Thoracolumbar Disc Replacement
Exhibit 3-28: US & Canadian Markets for Nuclear Arthroplasty
Exhibit 3-29: US Market for Nucleus Replacement
Exhibit 3-30: Total US Market for Vertebroplasty and Kyphoplasty
Exhibit 3-31: US Market for Vertebroplasty
Exhibit 3-32: US Market for Vertebroplasty
Exhibit 3-33: US Market for Kyphoplasty
Exhibit 3-34: US Market for Kyphoplasty
Exhibit 3-35: 2008 US Market Shares, Combined Vertebroplasty/Kyphoplasty
Exhibit 3-36: US Interspinous Process Spacers Market, 2008-2017
Exhibit 3-37: US Interspinous Process Spacers Market, 2008-2017
Exhibit 3-38: US Market for Image Guided Surgery Devices
Exhibit 3-39: US Market for Image Guided Surgery Devices
Exhibit 3-40: US Competitor Shares, Image Guided Surgery Devices, 2008
Exhibit 3-41: Total Global Spine Surgery Market, by Region, 2008
Exhibit 3-42: Total EU Spine Surgery Market, 2008-2017
Exhibit 3-43: Total EU Spine Surgery Market, 2008-2017
Exhibit 3-44: EU Spine Surgery Market by Segment, in USD
Exhibit 3-45: EU Spine Surgery Market by Percentage and Segments, 2008
Exhibit 3-46: EU Spine Surgery Market Shares, 2008
Exhibit 3-47: United Kingdom: Total Spine Surgery Market, 2008-2017
Exhibit 3-48: United Kingdom: Total Spine Surgery Market, 2008-2017
Exhibit 3-49: UK: Total Spine Surgery Market Shares, 2008
Exhibit 3-50: France: Total Spine Surgery Market, 2008-2017
Exhibit 3-51: France: Total Spine Surgery Market, 2008-2017
Exhibit 3-52: France: Total Spine Surgery Market Shares, 2008
Exhibit 3-53: Germany: Total Spine Surgery Market, 2008-2017
Exhibit 3-54: Germany: Total Spine Surgery Market, 2008-2017
Exhibit 3-55: Germany: Total Spine Surgery Market Shares, 2008
Exhibit 3-56: Italy: Total Spine Surgery Market, 2008-2017
Exhibit 3-57: Italy: Total Spine Surgery Market, 2008-2017
Exhibit 3-58: Italy: Total Spine Surgery Market Shares, 2008
Exhibit 3-59: Total EU Spine Fusion and Fixation Market, 2008-2017
Exhibit 3-60: Total EU Spine Fusion and Fixation Market, 2008-2017
Exhibit 3-61: United Kingdom: Spinal Fusion and Fixation Market, 2008-2017
Exhibit 3-62: France: Spinal Fusion and Fixation Market, 2008-2017
Exhibit 3-63: Germany: Spinal Fusion and Fixation Market, 2008-2017
Exhibit 3-64: Italy: Spine Fusion and Fixation Market, 2008-2017
Exhibit 3-65: Total EU Non-Fusion Market, 2008-2017
Exhibit 3-66: Total EU Non-Fusion Market, 2008-2017
Exhibit 3-67: United Kingdom: Non-fusion Products Market, 2008-2017
Exhibit 3-68: France: Total Non-Fusion Products Market, 2008-2017
Exhibit 3-69: Germany: Total Non-fusion Market, 2008-2017
Exhibit 3-70: Italy: Non-fusion Products Market, 2008-2017
Exhibit 3-71: Total EU Disc Replacement Market, 2008-2017
Exhibit 3-72: Total EU Disc Replacement Market, 2008-2017
Exhibit 3-73: United Kingdom: Total Disc Replacement Market, 2008-2017
Exhibit 3-74: France: Total Disc Replacement Market, 2008-2017
Exhibit 3-75: Germany: Total Disc Replacement Market, 2008-2017
Exhibit 3-76: Italy: Total Disc Replacement Market, 2008-2017
Exhibit 3-77: Total EU Nucleus Replacement Market, 2008-2017
Exhibit 3-78: Total EU Nucleus Replacement Market, 2008-2017
Exhibit 3-79: United Kingdom: Nucleus Replacement Market, 2008-2017
Exhibit 3-80: France: Nucleus Replacement Market, 2008-2017
Exhibit 3-81: Germany: Nucleus Replacement Market, 2008-2017
Exhibit 3-82: Italy: Nucleus Replacement Market, 2008-2017
Exhibit 3-83: Total EU Interspinous Process Spacers (ISPs) Market, 2008-2017
Exhibit 3-84: Total EU Interspinous Process Spacers (ISPs) Market, 2008-2017
Exhibit 3-85: United Kingdom: Interspinous Process Spacers Market, 2008-2017
Exhibit 3-86: France: Interspinous Process Spacers Market, 2008-2017
Exhibit 3-87: Germany: Total Spine Surgery Market, 2008-2017
Exhibit 3-88: Italy: Interspinous Process Spacers Market, 2008-2017
Exhibit 3-89: Total EU Kyphoplasty Market, 2008-2017
Exhibit 3-90: Total EU Vertebroplasty/Kyphoplasty Market, 2008-2017
Exhibit 3-91: United Kingdom: Vertebroplasty/Kyphoplasty Market, 2008-2017
Exhibit 3-92: France: Vertebroplasty/Kyphoplasty Market, 2008-2017
Exhibit 3-93: Germany: Vertebroplasty/Kyphoplasty Market, 2008-2017
Exhibit 3-94: Italy: Vertebroplasty/Kyphoplasty Market, 2008-2017
Exhibit 3-95: EU Market for Computer Assisted Image Guided Surgery Products, 2008-2017
Exhibit 3-96: United Kingdom: Image Guided Surgery Market, 2008-2017
Exhibit 3-97: France: Image Guided Surgery Market, 2008-2017
Exhibit 3-98: Germany: Image Guided Surgery Market, 2008-2017
Exhibit 3-99: Italy: Image Guided Surgery Market, 2008-2017
Exhibit 3-100: Asia-Pacific: Total Spine Surgery Market, 2008-2017
Exhibit 3-101: Asia-Pacific: Total Spine Surgery Market, 2008-2017
Exhibit 3-102: Asia-Pacific: Spine Surgery Market Shares, 2008
Exhibit 3-103: Asia-Pacific: Spinal Fusion and Fixation Market, 2008-2017
Exhibit 3-104: Asia-Pacific: Spinal Fusion and Fixation Market, 2008-2017
Exhibit 3-105: Asia-Pacific: Non-fusion Products Market, 2008-2017
Exhibit 3-106: Asia-Pacific: Non-fusion Products Market, 2008-2017
Exhibit 3-107: Asia-Pacific: Spinal Fusion vs. Non Fusion Markets, 2008 vs. 2017
Exhibit 3-108: Asia-Pacific: Total Disc Replacement Market, 2008-2017
Exhibit 3-109: Asia-Pacific: Total Disc Replacement Market, 2008-2017
Exhibit 3-110: Asia-Pacific: Nucleus Replacement Market, 2008-2017
Exhibit 3-111: Asia-Pacific: Nucleus Replacement Market, 2008-2017
Exhibit 3-112: Asia-Pacific: Interspinous Processes Market, 2008-2017
Exhibit 3-113: Asia-Pacific: Interspinous Processes Market, 2008-2017
Exhibit 3-114: Asia-Pacific: Vertebroplasty/Kyphoplasty Market, 2008-2017
Exhibit 3-115: Asia-Pacific: Vertebroplasty/Kyphoplasty Market, 2008-2017
Exhibit 3-116: Asia-Pacific: Image Guided Surgery Market, 2008-2017
Exhibit 3-117: Asia-Pacific: Image Guided Surgery Market, 2008-2017
Exhibit 3-118: Rest of World Spine Surgery Market Shares, 2008
Exhibit 3-119: ROW, Spine Surgery Markets, 2008-2017
Exhibit 3-120: ROW, Spine Surgery Markets, 2008-2017
Exhibit 3-121: ROW: Fusion and Fixation Market, 2008-2017
Exhibit 3-122: ROW: Fusion and Fixation Market, 2008-2017
Exhibit 3-123: ROW: Non-Fusion Market, 2008-2017
Exhibit 3-124: ROW: Total Disc Replacement Market, 2008-2017
Exhibit 3-125: ROW: Nucleus Replacement Market, 2008-2017
Exhibit 3-126: ROW: Interspinous Process Spacers Market, 2008-2017
Exhibit 3-127: ROW: Vertebroplasty/Kyphoplasty Market, 2008-2017
Exhibit 3-128: ROW: Image-Guided Surgery Market, 2008-2017

Exhibit 4-1: CPT spinal fusion codes now allowed by CMS
Exhibit 4-2: BCBSNC coverage of bone morphogenetic protein
Exhibit 4-3: New CMS codes for spinal motion preservation
Exhibit 4-4: Summary of CMS Medicare cost data

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This report is a detailed market and technology assessment and forecast of the products and technologies in the ablation market for treatment of soft tissues via energy-based modalities, including electrosurgery, radiosurgery, gamma knife, brachytherapy, cryogenic therapy, fluidjet therapy (hydrotherapy), microwave ablation, radiofrequency ablation, laser, thermal ablation, and ultrasonic ablation.

The report describes alternative energy-based technologies and the nature of their effect on soft tissue, the underlying basis of the technology, the requisite systems for their use (including capital equipment, devices and disposables), and their strengths and weaknesses for specific clinical applications. The report details current and anticipated target applications and assesses the current and forecast caseload for each energy-based therapeutic considering competition from any and all alternative energy-based or other therapeutics, with current and worldwide market forecasts (2008-2017) segmented by technology type and specific clinical segment. The report provides segmentation of the worldwide ablation market by both ablation technology and region/country: Americas (USA, Canada, Mexico, Brazil), Europe (Germany, United Kingdom, France, Italy, Spain, BeNeLux), Asia/Pacific (Japan, China, India, Australia) and Rest of World. The report details the current and emerging products, technologies and markets for each energy-based therapy. The report profiles over 60 key companies in this industry detailing their current products, current market position and products under development.

Table of Contents:

EXECUTIVE SUMMARY
Overview
Trends and Opportunities
Market Leaders

SECTION 1: ENERGY-BASED THERAPIES BY DISEASE STATE AND TECHNOLOGY
1.1 Cancer
1.1.1 Cryogenic therapy
1.1.2 Microwave therapy
1.1.3 Radiation therapy
1.1.4 Radiofrequency ablation
1.1.5 Stereotactic surgery
1.1.6 Thermal ablation
1.1.7 Laser ablation
1.1.8 Photodynamic therapy
1.1.9 Ultrasonic ablation
1.2 Cardiovascular disease
1.2.1 Angina pectoris
1.2.2 Atrial arrhythmias
1.2.2.1 Laser ablation
1.2.2.2 Cryoablation
1.2.2.3 Electrical cardioversion
1.2.2.4 Microwave ablation
1.2.2.5 RF ablation
1.2.3 Bradycardia
1.2.4 Critical ischaemia
1.2.5 Vascular occlusive disease
1.2.6 Ventricular arrhythmias
1.2.7 Wolf-Parkinson-White Disease
1.3 Elective surgery
1.3.1 Cosmetic surgery
1.3.1.1 Laser hair removal
1.3.1.2 Port wine stains
1.3.1.3 Psoriasis
1.3.1.4 Varicose veins
1.3.2 Ophthalmic surgery
1.3.2.1 Capsulotomy surgery
1.3.2.2 Laser in-situ keratomileusis (LASIK)
1.3.2.2.1 Wave-front guided laser in-situ keratomileusis
1.3.2.3 Laser epithelial keratomileusis (LASEK)
1.4 General surgery
1.4.1 Fecal incontinence
1.4.2 GERD
1.5 Gynecological applications
1.5.1 Hysterectomy
1.5.2 Menorrhagia
1.5.3 Bladder neck suspension
1.5.4 Fibroids
1.6 Urological applications
1.6.1 Urinary tract stones
1.6.2 Benign prostatic hypertrophy
1.6.2.1 TUMT
1.6.2.2 TUNA
1.6.2.3 Vaporization of the prostate (PVP)
1.6.2.4 Water-induced thermotherapy
1.7 Orthopedic applications
1.7.1 Capsular shrinkage
1.7.2 Carpal tunnel syndrome
1.7.3 Chondroplasty
1.7.4 Debridement
1.7.5 Epicondylitis and tendinitis
1.7.6 Inflammatory conditions
1.7.7 Nucleoplasty

Section 2: PRODUCTS AND TECHNOLOGIES
2.1 Cryogenic energy
2.2 Electrical energy
2.2.1 Implantable cardioverter defbibrillators
2.2.2 Resynchronisation systems
2.2.3 Pacing systems
2.2.4 Pain management
2.3 Hydromechanical energy
2.4 Light energy
2.4.1 Cold lasers
2.4.2 Excimer lasers
2.4.3 Photonic ablation
2.4.4 Ultraviolet B lasers
2.5 Microwave energy
2.6 Radiation energy
2.6.1 Brachytherapy
2.6.2 Radiosurgery
2.6.2.1 Cyberknife
2.6.2.2 Gamma knife
2.7 Radiofrequency energy
2.8 Thermal energy
2.9 Ultrasonic energy
2.9.2.1 Shock wave therapy
2.9.2.2 Ultrasonic surgical systems

Section 3: ABLATION TECHNOLOGIES MARKET
3.1 World market overview
3.2 Market segmentation by product type
3.3 Leading companies in global market
3.4 Major national markets
3.4.1 Americas
3.4.1.1 USA
3.4.1.2 Canada
3.4.1.3 Mexico
3.4.1.4 Brazil
3.4.2 Europe
3.4.2.1 Germany
3.4.2.2 United Kingdom
3.4.2.3 France
3.4.2.4 Italy
3.4.2.5 Spain
3.4.2.6 Benelux countries
3.4.3 Asia/Pacific
3.4.3.1 Japan
3.4.3.2 China
3.4.3.3 Australia
3.4.3.4 South Korea
3.4.3.5 India
3.4.4 Rest of world

Section 4: COMPANY PROFILES
4.1 The Industry
4.1.1 Abla-TX
4.1.1.1 Role in Cancer Treatment
4.1.2 Acoustic MedSystems
4.1.3 Accuray
4.1.4 ACMI/Gyrus/Olympus
4.1.5 AFx (Guidant)
4.1.6 Alcon
4.1.7 American Medical Systems
4.1.8 Angiodynamics
4.1.8.1 Financials
4.1.9 ArthroCare Corporation
4.1.10 AtriCure, Inc.
4.1.11 ATS Medical
4.1.11.1 Financial results
4.1.12 Bard EP
4.1.13 Bausch & Lomb (Warburg Pincus)
4.1.14 Baylis Medical Company
4.1.15 Biosense Webster
4.1.16 Biotronik Inc.
4.1.17 Biowave Corp
4.1.18 Boston Scientific Corp
4.1.18.1 Blazer Cardiac Ablation Catheters
4.1.18.2 Chilli Cooled Ablation Catheters
4.1.18.3 Steerocath-T Cardiac Ablation Catheter
4.1.18.4 Maestro
4.1.18.5 RF 3000® Radiofrequency Ablation System
4.1.18.6 Confient Implantable Cardioverter Defibrillator (ICD)
4.1.18.7 Financials
4.1.19 BSD Medical Corp.
4.1.19.1 MicroThermX-100 Microwave Ablation Systems
4.1.19.2 BSD500 Hyperthermia Systems
4.1.19.3 BSD2000 Hyperthermia Systems
4.1.20 Candela Corp.
4.1.21 Cardima Inc
4.1.22 CardioGenesis Corp
4.1.23 Celon AG
4.1.23.1 Surgery/Radiology
4.1.23.2 Phlebology
4.1.24 Celsion Corp.
4.1.25 ConMed Corp.
4.1.26 Covidien Ltd.
4.1.26.1 Vessel Sealing
4.1.26.2 Electrosurgery
4.1.26.3 Financial Results for fiscal 2007 and 2006
4.1.27 CryoCath
4.1.28 CryoCor, Inc.
4.1.29 CSA Medical Inc.
4.1.30 Cytyc Corp.
4.1.31 Dornier MedTech
4.1.31.1 Compact Delta II
4.1.31.2 Compact Delta II UIMS
4.1.31.3 Compact Sigma
4.1.31.4 Lithotripter S II
4.1.31.5 Medilas D MultiBeam
4.1.31.6 Medilas D FlexiPulse
4.1.31.7 Medilas H 20
4.1.32 EDAP TMS S.A.
4.1.32.1 Financial Update
4.1.33 Elekta
4.1.33.1 Leksell Gamma Knife 4
4.1.33.2 Leksell Gamma Knife 4C
4.1.33.3 Leksell Gamma Knife Perfexion
4.1.34 Endocare (merged with Galil Medical)
4.1.35 Erbe
4.1.35.1 Electrosurgery
4.1.35.2 Water Jet Surgery
4.1.35.3 Cryosurgery
4.1.36 Ethicon Endo-Surgery Inc.
4.1.37 Galil Medical (merged with Endocare)
4.1.38 Getinge Group
4.1.38.1 Cardiac Surgery
4.1.38.2 Vascular Surgery
4.1.39 HealthTronics Surgical Services
4.1.39.1 Medical Products
4.1.39.2 Urology Services
4.1.40 Medtronic
4.1.40.1 Cardiac Rhythm Disease Management (CRDM)
4.1.40.2 Bradycardia
4.1.40.3 Tachyarrhythmia
4.1.40.4 Ablation Catheters
4.1.41 MedWaves Inc.
4.1.42 Mirabilis Medica
4.1.43 Misonix Inc.
4.1.43.1 Sonablate
4.1.44 NeuWave Medical Inc.
4.1.45 Olympus Medical
4.1.46 OmniSonics Medical Technologies Inc. — filed for Chapter 7 bankruptcy in March 2009
4.1.47 PhotoMedex Inc.
4.1.48 PhotoTherapeutics Inc.
4.1.49 PhotoThera Inc.
4.1.50 RFA Medical Inc.
4.1.51 Smith & Nephew
4.1.51.1 Financial Results
4.1.52 Spectranetics
4.1.53 St Jude Medical Inc.
4.1.53.1 Products for Cardiac Rhythm Management
4.1.53.2 Atrial Fibrillation
4.1.53.3 Advanced Neuromodulation Systems
4.1.54 Starion Instruments
4.1.55 Stereotaxis Inc.
4.1.55.1 Stereotaxis Magnetic Navigation System
4.1.56 Theragenics Corporation
4.1.57 Urologix Inc
4.1.57.1 Targis System
4.1.58 USHIFU
4.1.59 Varian Medical Systems Inc.
4.1.59.1 RapidArc
4.1.59.2 Dynamic Targeting Image-Guided Radiation Therapy (IGRT)
4.1.59.3 SmartBeam IMRT
4.1.59.4 Dynamic Adaptive Radiotherapy (DART)
4.1.59.5 IGBT - Image-Guided Brachytherapy
4.1.59.6 Varian Proton Therapy System
4.1.60 VNUS Medical Technologies, Inc.
4.1.60.1 ClosureFAST System
4.1.60.2 Model RFG2 Advanced Radiofrequency Generator
4.1.60.3 Quarterly Financials
APPENDIX: COMPANY DETAILS

List of Exhibits

Exhibit ES-1: Overview of the Global Ablation and Other Energy-Based Therapies Market by Modality
Exhibit ES-2: Growth of the Worldwide Ablation and Other Energy-Based Therapies Market by Modality
Exhibit ES-3: Worldwide Ablation and Other Energy-Based Therapies Market by Clinical Application
Exhibit ES-4: Market Leaders in Energy-Based Therapies

Exhibit 1-1: Energy-Based Treatment Options for Prostate Cancer
Exhibit 1-2: Energy-Based Therapies for Cardiovascular Diseases
Exhibit 1-3: Energy-based Therapies for Atrial Arrhythmias
Exhibit 1-4: Ventricular Arrhythmia Therapies
Exhibit 1-5: Energy-based Implants for Ventricular Arrhythmias
Exhibit 1-6: Cosmetic Lasers
Exhibit 1-7: Traditional LAVH vs PK LVAH
Exhibit 1-8: Orthopedic Application of Electrosurgical Devices
Exhibit 1-9: Collagen Types
Exhibit 1-10: Chondroplasty Systems’ Zone of Thermal Damage

Exhibit 2-1: Energy-Based Technologies
Exhibit 2-2: Cryogenic-Energy Ablation Products
Exhibit 2-3: Electrical-Energy Ablation Products
Exhibit 2-4: Hydromechanical Ablation Products
Exhibit 2-5: Light-Energy Ablation Products
Exhibit 2-6: Microwave Ablation Products
Exhibit 2-7: Radiation-Energy Ablation Products
Exhibit 2-8: Radioactive Seed Products for Brachytherapy
Exhibit 2-9: Radiofrequency (RF) Ablation Products
Exhibit 2-10: Thermal-Energy Ablation Products
Exhibit 2-11: Ultrasound Ablation Products
Exhibit 2-12: High Growth Applications of Ultrasonic Surgical Systems

Exhibit 3-1: World Medical Device Market, by Region, 2008
Exhibit 3-2: World Energy-based Device Market by Product Category, 2007
Exhibit 3-3: Overview of the Energy-Based Therapies Market by Clinical Application
Exhibit 3-4: Arrhythmias Treated with Ablation Therapy
Exhibit 3-5: 25-Year Changes in National Mortality Rates Due to Ischaemic Heart Disease
Exhibit 3-6: Cardiac Angioplasty Procedures Per 100,000 Population, By Country in 2000
Exhibit 3-7: Cardiac Dysrhythmias and Related Conditions
Exhibit 3-8: Solid cancers: Ablation Market Potential
Exhibit 3-9: World Age-Standardize Cancer Incidence per 100, 000 Population (All Ages), by Cancer Type
Exhibit 3-10: Global Energy-based Therapies Market, by Product Category
Exhibit 3-11: World Energy-based Device Market by Product Category, 2007 and 2017
Exhibit 3-12: Ablation and Energy-based Therapeutic Companies by Product Area, Indication and Market Shares, Worldwide, 2008
Exhibit 3-13: Ablation Market Revenues ($millions), Americas, by Country, 2007-2017
Exhibit 3-14: Ablation Market Revenues ($000s) US, by Product Segment, 2007-2017
Exhibit 3-15: Ablation Market Revenues ($000s), Canada, by Product Segment, 2007-2017
Exhibit 3-16: Ablation Market Revenues ($000s), Brazil, by Product Segment, 2007-2017
Exhibit 3-17: Ablation Market Revenues ($000s), Mexico, by Product Segment, 2007-2017
Exhibit 3-18: Ablation Market Revenues ($millions), Europe, by Country, 2007-2017
Exhibit 3-19: Ablation Market Revenues ($000s), Germany, by Product Segment, 2007-2017
Exhibit 3-20: Ablation Market Revenues ($000s), United Kingdom, by Product Segment, 2007-2017
Exhibit 3-21: Ablation Market Revenues ($000s), France, by Product Segment, 2007-2017
Exhibit 3-22: Ablation Market Revenues ($000s), Italy, by Product Segment, 2007-2017
Exhibit 3-23: Ablation Market Revenues ($000s), Spain, by Product Segment, 2007-2017
Exhibit 3-24: Ablation Market Revenues ($000s), BeNeLux, by Product Segment, 2007-2017
Exhibit 3-25: Ablation Market Revenues ($millions), Asia/Pacific, by Country, 2007-2017
Exhibit 3-26: Ablation Market Revenues ($000s), Japan, by Product Segment, 2007-2017
Exhibit 3-27: Ablation Market Revenues ($000s), China, by Product Segment, 2007-2017
Exhibit 3-28: Ablation Market Revenues ($000s), India, by Product Segment, 2007-2017
Exhibit 3-29: Ablation Market Revenues ($000s), Australia, by Product Segment, 2007-2017
Exhibit 3-30: Ablation Market Revenues ($millions), Rest of World, 2007-2017
Exhibit 3-31: Ablation Market Revenues ($000s), Rest of World, by Product Segment, 2007-2017

Exhibit 4-1: M&A Activity Among Energy-based Companies
Exhibit 4-2: AngioDynamics Financial Figures for Fiscal 2007 and 2006
Exhibit 4-3: ATS Financial Results for Q2 2008 and 2007
Exhibit 4-4: Boston Scientific Financials, Three Months Ended June 30, 2007 & 2008
Exhibit 4-5: CardioGenesis Financial Data, 2006 &2007
Exhibit 4-6: Covidien Ltd Financial Results, 2006 & 2007
Exhibit 4-7: Covidien Medical Device sales by Product Group
Exhibit 4-8: EDAP TMS Financial Results, 1st Quarter 2008 (to March 31st)
Exhibit 4-9: Endocare Quarterly Results, 2007 & 2008
Exhibit 4-10: Medtronic Revenues, 2007
Exhibit 4-11: Six-month Financial Data for Smith & Nephew, 2007 & 2008
Exhibit 4-12: TheraGenics Financial Results, Fourth Quarter 2007 and Full Year
Exhibit 4-13: Varian Medical Systems, Financial Summary, 2005-2007

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This report details the complete range of sealants & glues technologies used in traumatic, surgical and other wound closure, from tapes, sutures and staples to hemostats, fibrin sealants/glues and medical adhesives. The report details current clinical and technology developments in this huge and rapidly growing worldwide market, with data on products in development and on the market; market size and forecast; competitor market shares; competitor profiles; and market opportunity.

This report is a market and technology assessment and forecast of surgical sealants, glues, hemostasis, other wound closure and anti-adhesion. The report details the current and emerging products, technologies and markets involved in wound closure and sealing using sutures and staples, tapes, hemostats, fibrin and sealant products, medical adhesives and products to prevent surgical adhesions. The report provides a worldwide current and annual forecast to 2013 of the markets for these technologies, with particular emphasis on the market impact of new technologies through the coming decade. The report provides specific forecasts and shares of the worldwide market by segment for the U.S., Europe (United Kingdom, German, France, Italy, BeNeLux), Latin America, Japan and Rest of World.

The report provides background data on the surgical, disease and traumatic wound patient populations targeted by current technologies and those under development, and the current clinical practices in the management of these patients, including the dynamics among the various clinical specialties or subspecialties vying for patient population and facilitating or limiting the growth of technologies.

The report establishes the current worldwide market size for major technology segments as a baseline for and projecting growth in the market over a ten-year forecast. The report also assesses and projects the composition of the market as technologies gain or lose relative market performance over this period.

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This report details the complete range of products and technologies in spine surgery, including the surgical management of spine disorders, diseases and trauma, with treatments including use of grafts, demineralized bone, fusion, stabilization, disc replacement, nucleus replacement, vertebroplasty, kyphoplasty, imaging, minimally invasive surgical technologies, energy-based therapies and biologics. The report details current clinical and technology developments in the huge and rapidly growing spine surgery technologies worldwide market, with data on products in development and on the market; market size and forecast; competitor market shares; competitor profiles; and market opportunity.

This report is a detailed market and technology assessment and forecast of the products and technologies in the management of diseases and disorders of the spine. The report describes diseases and disorders of the spine, encompassing congenital disorders, inflammatory and infectious diseases; degenerative diseases; herniations, stenoses, myelopathies and other “mechanical” disorders of the spine; spinal trauma; tumors of the spine; and others. The report characterizes the patient populations, their current clinical management, and trends in clinical management as new techniques and technologies are expected to be developed and emerge. The report details the currently available products and technologies, and manufacturer offerings. The report details products and technologies under development and markets for each in spine surgery. The report provides a current and forecast assessment of the worldwide markets for these technologies, with geographic segmentation by U.S. & Canada, European Union (detailing France, United Kingdom, Germany, Italy and Spain), Japan and Rest of World. The report provides emphasis on the market impact of new technologies through the coming decade, profiling nearly 100 active companies in this industry, with comprehensive detail on key companies, providing data on their current products, current market position and products under development.

Table of Contents:

Executive Summary
Non-fusion products
Disc arthroplasty (total disc replacement)
Nuclear arthroplasty
European Union
Asia-Pacific
Rest of World
Selected company-related events
Medtronic
LDR Spine
Synthes Spine
Disc Motion Technologies
Spine Structure
Products and technologies
CMS, carriers reverse decision on artificial discs
Cost effectiveness

Section 1:          The Spine: Structure, Disorders, Treatment
1.1         Overview: Spine Structure
1.2         Diseases and disorders of the spine
1.2.1             Congenital Disorders
1.2.2             Inflammatory and Infectious Diseases of the Spine
1.2.3             Degenerative Diseases of the Spine
1.2.4             Mechanical Disorders of the Spine
1.2.5             Spinal Trauma
1.2.6             Tumors of the Spine
1.3         Spine management
1.3.1             Clinical: the SPORT Study
1.3.2             Diagnostic studies
1.3.3             Surgical procedures of the spine
1.3.4             Minimally Invasive Procedures
1.3.5             Minimally Invasive Bone Grafting Procedures
1.3.6             Acupuncture for treatment of chronic low back pain

Section 2:          Products and Technologies
2.1         Bone grafts and bone graft substitutes
2.2         Demineralized bone matrix (DBM)
2.2.1             Particle based DBM
2.2.2             Biomimetic matrix bone substitute
2.2.3             Bone morphogenic proteins (BMPs)
2.3         Spinal fusion and fixation products and technologies
2.3.1             Spine surgery instrumentation
2.3.2             Cervical fusion devices
2.3.3             Interbody fusion devices
2.3.4             Posterior dynamic stabilization systems
2.4         Non-fusion products and technologies
2.4.1             Disc arthroplasty
2.4.2             Nuclear arthroplasty and nuclear disc prostheses
2.4.3             Facet repair and replacement
2.5         Vertebroplasty and kyphoplasty
2.5.1             Vertebral compression fracture treatment technologies
2.6         Advances in spinal image-guided surgery
2.6.1             Medtronic’s StealthStation
2.6.2             GE Healthcare’s Fluoro-Spine
2.6.3             Elekta’s Axesse system
2.6.4             Zimmer’s ORTHOsoft Navitrack® FluoroSpine® System
2.7         Products and technologies for minimally invasive spinal surgery
2.7.1             ArthroCare’s spineWand
2.7.2             Medtronic’s MAST™ portfolio
2.7.3             NuVasive’s Maximum Access Surgery (MAS)
2.7.4             Abbott Spine’s Harmony Retractor
2.7.5             Globus transforaminal TDR device
2.8         Energy-based therapies
2.8.1             Bone growth stimulators
2.8.2             Intradiscal Electrothermal Therapy (IDET)
2.9         Biologics

Section 3:          Market Size, Forecast and Competitor Shares
3.1         Global market size, forecast and competitor shares
3.2         USA & Canada
3.2.1             Bone grafts and bone graft substitutes
3.2.2             Spinal fusion and fixation products
3.2.3             Non-fusion products
3.2.4             Vertebroplasty and Kyphoplasty
3.2.5             Interspinous process spacers (ISP)
3.2.6             Computer assisted image guided surgery products
3.3         European Union
3.3.1             United Kingdom
3.3.2             France
3.3.3             Germany
3.3.4             Italy
3.3.5             Spinal fusion and fixation products
3.3.6             Non-fusion products
3.3.7             Total disc replacement
3.3.8             Nucleus replacement
3.3.9             Interspinous process spacers (ISPs)
3.3.10           Kyphoplasty
3.3.11           Image Guided Surgery Products Market
3.4         Asia-Pacific
3.4.1             Spinal fusion and fixation products
3.4.2             Non-fusion products
3.4.3             Image guided surgery products
3.5         Rest of World

Section 4:          Regulatory, Cost and Reimbursement Issues
4.1         Regulatory Issues Associated with Spine Treatments, Materials and Methods
4.1.1             Regulatory issues regarding off-label usage
4.1.2             Changes to European Device Safety Regulations
4.1.3             NICE and dynamic stabilization procedures
4.2         Reimbursement Developments
4.2.1             CMS, carriers reverse decision on artificial discs
4.2.2             CMS reverses stand on two spinal fusion procedures
4.2.3             ArthroCare and DiscoCare
4.2.4             Bone growth factor reimbursement issues
4.2.5             CMS investigates Thermal Intradiscal Therapy
4.2.6             CMS announces new ICD-9-CM spinal procedure codes
4.2.7             Wellmark and energy-based treatments
4.3         Cost effectiveness

Section 5:          Company Profiles
5.1         Abbott Spine
5.2         AlloSource
5.3         Alphatec Holdings, Inc.
5.4         Altiva Corporation
5.5         Anulex Technologies, Inc.
5.6         ApaTech
5.7         Applied Spine Technologies
5.8         ArthroCare Corporation
5.9         A-Spine Holding Group Corporation
5.10       Axial Biotech
5.11       AxioMed Spine Corporation
5.12       B. Braun/Aesculap, Inc.
5.13       BioAssets Development Corporation
5.14       Biomet
5.15       Biorthex, Inc.
5.16       Blackstone Medical, Inc
5.17       BrainLAB
5.18       Cardinal Health
5.19       Cervitech
5.20       Changzhou Kanghui
5.21       Co.Don AG
5.22       CoLigne AG
5.23       Cook Group
5.24       CoreSpine Technologies LLC
5.25       Corin Group
5.26       Cortek, Inc
5.27       Cryolife, Inc.
5.28       Cyberkinetics Neurotechnology Systems
5.29       Cytori Therapeutics
5.30       DePuy Spine/J&J
5.31       Disc Dynamics
5.32       Disc Motion Technologies
5.33       Encore Medical Corporation / DJO Surgical (ReAble Therapeutics)
5.34       Facet Solutions
5.35       Fixano (Small Bone Innovations)
5.36       GE Healthcare
5.37       Gentis, Inc
5.38       Globus Medical
5.39       GMReis
5.40       HydroCision
5.41       [Innovative Spinal Technologies — ceased operations January 2009]
5.42       Integra LifeSciences
5.43       Integra Radionics
5.44       Interpore Cross
5.45       Interventional Spine
5.46       Invibio
5.47       LDR Holding Corporation
5.48       LifeNet Health, Inc.
5.49       Mazor Surgical Technologies Ltd
5.50       Medtronic, Inc
5.51       Medtronic Sofamor Danek
5.52       Medtronic Surgical Navigation
5.53       Mekanika, Inc.
5.54       Merck & Co., Inc.
5.55       MiMedx
5.56       Misonix
5.57       MTF (Musculoskeletal Transplant Foundation)
5.58       NPS Pharmaceuticals
5.59       N Spine, Inc. (Synthes)
5.60       NuVasive, Inc.
5.61       Ortho Development Corporation
5.62       Orthofix International, N.V.
5.63       OrthoVita
5.64       Osiris Therapeutics
5.65       Osteotech, Inc.
5.66       Ortosintese
5.67       Paradigm Spine, LLC
5.68       Pitkar
5.69       Praxim
5.70       Ranier Technology Limited
5.71       Raymedica, Inc.
5.72       Regeneration Technologies, Inc
5.73       Scient’X
5.74       SeaSpine, Inc.
5.75       Sharma Surgical
5.76       Small Bone Innovations, LLC
5.77       Smart Disc
5.78       Smith & Nephew
5.79       SpinalMotion
5.80       SpineMedica Corporation
5.81       Spineology
5.82       SpineOvations
5.83       SpineVision Inc
5.84       Spine Wave, Inc.
5.85       Stryker Corporation
5.86       Stryker Instruments
5.87       Stryker Spine
5.88       Synthes Spine Solutions
5.89       Theken Spine
5.90       TranS1, Inc.
5.91       Trimedyne, Inc.
5.92       Ulrich Medical GmbH
5.93       Valleylab
5.94       Vertebron Inc.
5.95       Waston Medical
5.96       Wright Medical Technology
5.97       X-spine Systems, Inc.
5.98       Zimmer Spine
Appendix:  Company Directory

List of Exhibits

Exhibit ES-1: Total Global Spine Surgery Market, 2008-2017
Exhibit ES-2: Total Global Spine Surgery Market, 2008-2017
Exhibit ES-3: Global Spine Surgery Market by Segment, in USD Terms
Exhibit ES-4: Global Spine Surgery Market by Percentage and Segments, 2008
Exhibit ES-5: Major Spine Market Segments, 2008-2017
Exhibit ES-6: Key Factors Driving Growth in the Global Spine Surgery Market
Exhibit ES-7: Global Spine Surgery Market Shares, 2008
Exhibit ES-8: US & Canadian Market for Spine Surgery Devices
Exhibit ES-9: US Company Market Shares for Spine Surgery Devices, 2008
Exhibit ES-10: Total Global Spine Surgery Market, by Region, 2008
Exhibit ES-11: Total EU Spine Surgery Market, 2008-2017
Exhibit ES-12: Total EU Spine Surgery Market, 2008-2017
Exhibit ES-13: EU Spine Surgery Market Shares, 2008
Exhibit ES-14: Asia-Pacific: Total Spine Surgery Market, 2008-2017
Exhibit ES-15: Asia-Pacific: Total Spine Surgery Market, 2008-2017
Exhibit ES-16: Asia-Pacific: Spine Surgery Market Shares, 2008
Exhibit ES-17: Rest of World Spine Surgery Market Shares, 2008
Exhibit ES-18: ROW, Spine Surgery Markets, 2008-2017
Exhibit ES-19: Lateral and Posterior Views of the Spine
Exhibit ES-20: Human Spine Structure Showing Vertebrae, Intervertebral Discs, and Spinal Cord
Exhibit ES-21: US Census figures and projections, ages 65 and up, 1900-2050.
Exhibit ES-22: Number & Percentage of U.S. Population over Age 65, 1910–2050
Exhibit ES-23: Mechanical Disorders of the Spine
Exhibit ES-24: Start-up companies and areas of interest
Exhibit ES-25: CPT spinal fusion codes now allowed by CMS
Exhibit ES-26: Summary of CMS Medicare cost data

Exhibit 1-1: Lateral and Posterior Views of the Spine
Exhibit 1-2: Human Spine Structure Showing Vertebrae, Intervertebral Discs, and Spinal Cord
Exhibit 1-3: Components of the Human Spine
Exhibit 1-4: US Census figures and projections, ages 65 and up, 1900-2050.
Exhibit 1-5: Number & Percentage of U.S. Population over Age 65, 1910–2050
Exhibit 1-6: Congenital Disorders of the Spine
Exhibit 1-7: Inflammatory and Infectious Diseases of the Spine
Exhibit 1-8: Degenerative Diseases of the Spine
Exhibit 1-9: Estimated Annual Number of Fractures Due to Osteoporosis in the U.S. (Total: Over 1.5 Million)
Exhibit 1-10: Mechanical Disorders of the Spine
Exhibit 1-11: Location, Effects, and Incidence of Major Lumbar Disc Herniations
Exhibit 1-12: Clinical Features—Radiculopathy by Spinal Level
Exhibit 1-13: Causes of Trauma to Spinal Regions
Exhibit 1-14: Tumors of the Spine
Exhibit 1-15: Traditional (“Open”) Spinal Procedures
Exhibit 1-16: Estimated Number of Spinal Fusion Procedures Performed in the U.S., 2005–2015
Exhibit 1-17: Minimally Invasive Spinal Procedures

Exhibit 2-1: Spinal Allografts: Vendors and Products
Exhibit 2-2: Hydroxyapatite Bone Substitutes: Vendors, Products
Exhibit 2-3: Bone growth stimulatory proteins, peptides and devices
Exhibit 2-4: Fusion instrumentation companies
Exhibit 2-5: Developers of Interspinous Process Spacers
Exhibit 2-6: Developers of Total Disc Replacements
Exhibit 2-7: Artificial Cervical Discs Currently in US Clinical Trials
Exhibit 2-8: Artificial Cervical Discs Currently Available in the EU
Exhibit 2-9: Total disc replacement devices
Exhibit 2-10: Developers of Prosthetic Disc Nuclei
Exhibit 2-11: Nucleus replacement implants
Exhibit 2-12: Current nucleus arthroplasty motion preservation IDE pilot studies
Exhibit 2-13: Bone growth stimulatory proteins, peptides and devices
Exhibit 2-14: Cellular therapies: manufacturers and product
Exhibit 2-15: Other start-up companies and areas of interest

Exhibit 3-1: Total Global Spine Surgery Market, 2008-2017
Exhibit 3-2: Total Global Spine Surgery Market, 2008-2017
Exhibit 3-3: Global Spine Surgery Market by Segment, in USD Terms
Exhibit 3-4: Global Spine Surgery Market by Percentage and Segments, 2008
Exhibit 3-5: Key Factors Driving Growth in the Global Spine Surgery Market
Exhibit 3-6: Major Spine Market Segments, 2008-2017
Exhibit 3-7: Global Spine Surgery Market Shares, 2008
Exhibit 3-8: US & Canadian Market for Spine Surgery Devices
Exhibit 3-9: US & Canadian Market for Spine Surgery Devices
Exhibit 3-10: US Company Market Shares for Spine Surgery Devices, 2008
Exhibit 3-11: Usage of Bone Grafts and Bone Graft Substitutes in Spinal Fusion Procedures (excluding BMPs)
Exhibit 3-12: US Market for Bone Graft Substitutes
Exhibit 3-13: US Market for Spine-Related Orthobiologics, 2008-2017
Exhibit 3-14: US & Canadian Market for Spinal Fusion and Fixation Devices
Exhibit 3-14B:  US & Canadian Spinal Fusion Procedures by Segment (Cervical, Lumbar, Thoracic), 2008-2017
Exhibit 3-15: Number of Spinal Fusions
Exhibit 3-16: US & Canadian Market for Spinal Fusion and Fixation Devices
Exhibit 3-17: US Market Shares, Spinal Fusion and Fixation Devices, 2008
Exhibit 3-18: US Market Shares, Spinal Fusion and Fixation Devices, 2008
Exhibit 3-19 Total US Non-Fusion Device Market
Exhibit 3-20: Total US Non-Fusion Device Market
Exhibit 3-21: US Annulus Repair Market, 2009-2015
Exhibit 3-22: US Annulus Repair Market, 2009-2015
Exhibit 3-23: Total Market for Disc Arthroplasty (Cervical Plus Thoracolumbar)
Exhibit 3-24: US Market for Cervical Disc Replacement
Exhibit 3-25: US Market for Cervical Disc Replacement
Exhibit 3-26: US Market for Thoracolumbar Disc Replacement
Exhibit 3-27: US Market for Thoracolumbar Disc Replacement
Exhibit 3-28: US & Canadian Markets for Nuclear Arthroplasty
Exhibit 3-29: US Market for Nucleus Replacement
Exhibit 3-30: Total US Market for Vertebroplasty and Kyphoplasty
Exhibit 3-31: US Market for Vertebroplasty
Exhibit 3-32: US Market for Vertebroplasty
Exhibit 3-33: US Market for Kyphoplasty
Exhibit 3-34: US Market for Kyphoplasty
Exhibit 3-35: 2008 US Market Shares, Combined Vertebroplasty/Kyphoplasty
Exhibit 3-36: US Interspinous Process Spacers Market, 2008-2017
Exhibit 3-37: US Interspinous Process Spacers Market, 2008-2017
Exhibit 3-38: US Market for Image Guided Surgery Devices
Exhibit 3-39: US Market for Image Guided Surgery Devices
Exhibit 3-40: US Competitor Shares, Image Guided Surgery Devices, 2008
Exhibit 3-41: Total Global Spine Surgery Market, by Region, 2008
Exhibit 3-42: Total EU Spine Surgery Market, 2008-2017
Exhibit 3-43: Total EU Spine Surgery Market, 2008-2017
Exhibit 3-44: EU Spine Surgery Market by Segment, in USD
Exhibit 3-45: EU Spine Surgery Market by Percentage and Segments, 2008
Exhibit 3-46: EU Spine Surgery Market Shares, 2008
Exhibit 3-47: United Kingdom: Total Spine Surgery Market, 2008-2017
Exhibit 3-48: United Kingdom: Total Spine Surgery Market, 2008-2017
Exhibit 3-49: UK: Total Spine Surgery Market Shares, 2008
Exhibit 3-50: France: Total Spine Surgery Market, 2008-2017
Exhibit 3-51: France: Total Spine Surgery Market, 2008-2017
Exhibit 3-52: France: Total Spine Surgery Market Shares, 2008
Exhibit 3-53: Germany: Total Spine Surgery Market, 2008-2017
Exhibit 3-54: Germany: Total Spine Surgery Market, 2008-2017
Exhibit 3-55: Germany: Total Spine Surgery Market Shares, 2008
Exhibit 3-56: Italy: Total Spine Surgery Market, 2008-2017
Exhibit 3-57: Italy: Total Spine Surgery Market, 2008-2017
Exhibit 3-58: Italy: Total Spine Surgery Market Shares, 2008
Exhibit 3-59: Total EU Spine Fusion and Fixation Market, 2008-2017
Exhibit 3-60: Total EU Spine Fusion and Fixation Market, 2008-2017
Exhibit 3-61: United Kingdom: Spinal Fusion and Fixation Market, 2008-2017
Exhibit 3-62: France: Spinal Fusion and Fixation Market, 2008-2017
Exhibit 3-63: Germany: Spinal Fusion and Fixation Market, 2008-2017
Exhibit 3-64: Italy: Spine Fusion and Fixation Market, 2008-2017
Exhibit 3-65: Total EU Non-Fusion Market, 2008-2017
Exhibit 3-66: Total EU Non-Fusion Market, 2008-2017
Exhibit 3-67: United Kingdom: Non-fusion Products Market, 2008-2017
Exhibit 3-68: France: Total Non-Fusion Products Market, 2008-2017
Exhibit 3-69: Germany: Total Non-fusion Market, 2008-2017
Exhibit 3-70: Italy: Non-fusion Products Market, 2008-2017
Exhibit 3-71: Total EU Disc Replacement Market, 2008-2017
Exhibit 3-72: Total EU Disc Replacement Market, 2008-2017
Exhibit 3-73: United Kingdom: Total Disc Replacement Market, 2008-2017
Exhibit 3-74: France: Total Disc Replacement Market, 2008-2017
Exhibit 3-75: Germany: Total Disc Replacement Market, 2008-2017
Exhibit 3-76: Italy: Total Disc Replacement Market, 2008-2017
Exhibit 3-77: Total EU Nucleus Replacement Market, 2008-2017
Exhibit 3-78: Total EU Nucleus Replacement Market, 2008-2017
Exhibit 3-79: United Kingdom: Nucleus Replacement Market, 2008-2017
Exhibit 3-80: France: Nucleus Replacement Market, 2008-2017
Exhibit 3-81: Germany: Nucleus Replacement Market, 2008-2017
Exhibit 3-82: Italy: Nucleus Replacement Market, 2008-2017
Exhibit 3-83: Total EU Interspinous Process Spacers (ISPs) Market, 2008-2017
Exhibit 3-84: Total EU Interspinous Process Spacers (ISPs) Market, 2008-2017
Exhibit 3-85: United Kingdom: Interspinous Process Spacers Market, 2008-2017
Exhibit 3-86: France: Interspinous Process Spacers Market, 2008-2017
Exhibit 3-87: Germany: Total Spine Surgery Market, 2008-2017
Exhibit 3-88: Italy: Interspinous Process Spacers Market, 2008-2017
Exhibit 3-89: Total EU Kyphoplasty Market, 2008-2017
Exhibit 3-90: Total EU Vertebroplasty/Kyphoplasty Market, 2008-2017
Exhibit 3-91: United Kingdom: Vertebroplasty/Kyphoplasty Market, 2008-2017
Exhibit 3-92: France: Vertebroplasty/Kyphoplasty Market, 2008-2017
Exhibit 3-93: Germany: Vertebroplasty/Kyphoplasty Market, 2008-2017
Exhibit 3-94: Italy: Vertebroplasty/Kyphoplasty Market, 2008-2017
Exhibit 3-95: EU Market for Computer Assisted Image Guided Surgery Products, 2008-2017
Exhibit 3-96: United Kingdom: Image Guided Surgery Market, 2008-2017
Exhibit 3-97: France: Image Guided Surgery Market, 2008-2017
Exhibit 3-98: Germany: Image Guided Surgery Market, 2008-2017
Exhibit 3-99: Italy: Image Guided Surgery Market, 2008-2017
Exhibit 3-100: Asia-Pacific: Total Spine Surgery Market, 2008-2017
Exhibit 3-101: Asia-Pacific: Total Spine Surgery Market, 2008-2017
Exhibit 3-102: Asia-Pacific: Spine Surgery Market Shares, 2008
Exhibit 3-103: Asia-Pacific: Spinal Fusion and Fixation Market, 2008-2017
Exhibit 3-104: Asia-Pacific: Spinal Fusion and Fixation Market, 2008-2017
Exhibit 3-105: Asia-Pacific: Non-fusion Products Market, 2008-2017
Exhibit 3-106: Asia-Pacific: Non-fusion Products Market, 2008-2017
Exhibit 3-107: Asia-Pacific: Spinal Fusion vs. Non Fusion Markets, 2008 vs. 2017
Exhibit 3-108: Asia-Pacific: Total Disc Replacement Market, 2008-2017
Exhibit 3-109: Asia-Pacific: Total Disc Replacement Market, 2008-2017
Exhibit 3-110: Asia-Pacific: Nucleus Replacement Market, 2008-2017
Exhibit 3-111: Asia-Pacific: Nucleus Replacement Market, 2008-2017
Exhibit 3-112: Asia-Pacific: Interspinous Processes Market, 2008-2017
Exhibit 3-113: Asia-Pacific: Interspinous Processes Market, 2008-2017
Exhibit 3-114: Asia-Pacific: Vertebroplasty/Kyphoplasty Market, 2008-2017
Exhibit 3-115: Asia-Pacific: Vertebroplasty/Kyphoplasty Market, 2008-2017
Exhibit 3-116: Asia-Pacific: Image Guided Surgery Market, 2008-2017
Exhibit 3-117: Asia-Pacific: Image Guided Surgery Market, 2008-2017
Exhibit 3-118: Rest of World Spine Surgery Market Shares, 2008
Exhibit 3-119: ROW, Spine Surgery Markets, 2008-2017
Exhibit 3-120: ROW, Spine Surgery Markets, 2008-2017
Exhibit 3-121: ROW: Fusion and Fixation Market, 2008-2017
Exhibit 3-122: ROW: Fusion and Fixation Market, 2008-2017
Exhibit 3-123: ROW: Non-Fusion Market, 2008-2017
Exhibit 3-124: ROW: Total Disc Replacement Market, 2008-2017
Exhibit 3-125: ROW: Nucleus Replacement Market, 2008-2017
Exhibit 3-126: ROW: Interspinous Process Spacers Market, 2008-2017
Exhibit 3-127: ROW: Vertebroplasty/Kyphoplasty Market, 2008-2017
Exhibit 3-128: ROW: Image-Guided Surgery Market, 2008-2017

Exhibit 4-1: CPT spinal fusion codes now allowed by CMS
Exhibit 4-2: BCBSNC coverage of bone morphogenetic protein
Exhibit 4-3: New CMS codes for spinal motion preservation
Exhibit 4-4: Summary of CMS Medicare cost data

For more information kindly visit
http://www.bharatbook.com/Market-Research-Reports/Spine-Surgery-Worldwide-2008-2017-Products-Technologies-Markets-and-Opportunities.html

Worldwide Market for Drug-Eluting, Bare and Other Coronary Stents, 2008-2017

This report details the worldwide market for the use of alternative stent devices in the treatment of coronary artery disease. The report assesses the treatment of coronary artery disease by alternative treatment methodologies (percutaneous intervention with or without stenting, coronary artery bypass grafting alternatives and other medical/surgical treatment options), with estimated current/forecast caseload across treatment types.

The report provides full year (actual) 2008 market size and share data, with forecast market data to 2017, for the U.S., Europe, Asia/Pacific and Rest of World.

The report details currently approved coronary stents, providing data on current and forecast impact on the market. The report also details the current state of product development in bare stents, drug-coated or drug-eluting stents and bioabsorbable stents in coronary applications and details the products under development, the anticipated timeline and impact of their market introduction. The report assesses the current and ten-year forecast global market for coronary stents, with segmentation by U.S., Europe, Asia/Pacific and Rest of World. The report provides competitor market shares by these geographic regions. The leading and key emerging coronary stent manufacturers are profiled with current product offerings, development status and market strengths/advantages.

Table of Contents:

EXECUTIVE SUMMARY

SECTION 1:   CLINICAL BACKGROUND

1.1       Cardiovascular Disorders Applicable for Stent Implantation
1.1.1    Acute Closure
1.1.2    Restenosis After Angioplasty
1.2       Risk Factors for Coronary Heart Disease
1.3       Stenting vs. CABG and Angioplasty
1.4       Alternative Therapies for Coronary Atherosclerosis
1.4.1    Angioplasty With or Without Stenting
1.4.2    Atherectomy
1.4.3    Coronary Artery Bypass Graft (CABG)
1.4.3.1 Open CABG
1.4.3.2 Off-Pump Coronary Artery Bypass (OPCAB)
1.4.3.3 MIDCAB (Minimally Invasive Direct Coronary Bypass)
1.4.3.4 RACAB (Robotic Assisted Coronary Artery Bypass)
1.4.3.5 Other Forms of CABG
1.4.4    Transmyocardial Laser Revascularization (TMR)
1.4.5    Genetic Therapies
1.4.6    HDL Therapy
1.4.7    Drug-Eluting Balloons
1.4.8    Nanoparticles and Other Agents
1.5       Incidence and Prevalence of Cardiovascular Stenting Procedures
1.6       Complications Related to Cardiovascular Stents

SECTION 2:   PRODUCTS, TECHNOLOGIES
2.1       Materials Used in Cardiovascular Stents
2.2       Various Stent Shapes and Resulting Impact
2.3       FDA Approval of Cardiovascular Stents
2.4       Reimbursement of Drug-Eluting Stents
2.5       Bare Metal Stents
2.6       Drug-Eluting Stents
2.6.1    Abbott Vascular
2.6.2    Boston Scientific
2.6.3    Johnson & Johnson/Cordis
2.6.4    Medtronic
2.6.5    Other Drug-Eluting Stent Companies
2.7       Bioabsorbable Stents
2.8       Other Types of Stents
2.9       Legal Proceedings
2.10     Key Clinical Trials
2.10.1  HORIZONS AMI
2.10.2  SYNTAX
2.10.3  SPIRIT
2.10.4  COURAGE
2.10.5  PROTECT
2.10.6  ENDEAVOR
2.10.7  FAME
2.10.8  SORT OUT III
2.10.9  DAPT
2.10.10  ZEST

SECTION 3:   MARKETS FORECASTS AND COMPETITOR SHARES
3.1       Worldwide Market for Coronary Stents
3.1.1    Worldwide Market for Drug-Eluting Coronary Stents
3.1.2    Worldwide Market for Bare Metal Coronary Stents
3.1.3    Worldwide Market for Absorbable Coronary Stents
3.2       U.S. Market for Coronary Stents
3.2.1    U.S. Market for Drug-Eluting Coronary Stents
3.2.2    U.S. Market for Bare Metal Coronary Stents
3.2.3    U.S. Market for Absorbable Coronary Stents
3.3       European Market for Coronary Stents
3.3.1    European Market for Drug-Eluting Coronary Stents
3.3.2    European Market for Bare Metal Coronary Stents
3.3.3    European Market for Absorbable Coronary Stents
3.4       Asia/Pacific Market for Coronary Stents
3.4.1    Asia/Pacific Market for Drug-Eluting Coronary Stents
3.4.2    Asia/Pacific Market for Bare Metal Coronary Stents
3.4.3    Asia/Pacific Market for Absorbable Coronary Stents
3.5       Rest of World (ROW) Market for Coronary Stents
3.5.1    ROW Market for Drug-Eluting Coronary Stents
3.5.2    ROW Market for Bare Metal Coronary Stents
3.5.3    ROW Market for Absorbable Coronary Stents

SECTION 4:   COMPANY PROFILES
4.1       Aachen Resonance GmbH
4.2       Abbott Vascular
4.3       AdvanSource Biomaterials Corporation
4.4       Aeon Bioscience
4.5       Allvivo Vascular, Inc.
4.6       Amaranth Medical, Inc.
4.7       amg International GmbH
4.8       Arterial Remodeling Technologies (ART)
4.9       Atrium Medical
4.10     Avantec Vascular
4.11     B. Braun Melsungen
4.12     Balton Ltd.
4.13     Bioabsorbable Therapeutics, Inc.
4.14     Bioring SA
4.15     Biosensors International
4.16     Biotronik
4.17     Blue Medical Devices B.V.
4.18     Boston Scientific
4.19     Caliber Therapeutics
4.20     Cappella Inc.
4.21     CardioMind, Inc.
4.22     CeloNova BioSciences, Inc.
4.23     CID S.r.l. (Formerly Sorin Vascular Therapy)
4.24     Cinvention AG (Formerly Blue Membranes)
4.25     CorNova
4.26     CV Therapeutics/Gilead Inc.
4.27     Devax
4.28     DISA Vascular
4.29     Elixir Medical Corp.
4.30     Estracure Inc.
4.31     eucatech AG
4.32     Genesis Technologies, LLC
4.33     Global Therapeutics (Cook Medical)
4.34     Hexacath
4.35     ICON Interventional (Formerly ICON Medical Corp.)
4.36     InspireMD
4.37     InTek Technology
4.38     Invatec s.r.l.
4.39     ITGI Medical Ltd.
4.40     Johnson & Johnson
4.40.1  Cordis
4.40.2  Conor Medsystems (J&J)
4.41     JW Medical Systems / Biosensors International
4.42     Kaneka Corporation
4.43     Kyoto Medical Planning Co., Ltd.
4.44     Lepu Medical
4.45     Lutonix, Inc.
4.46     Medinol/ARIAD Pharmaceuticals
4.47     Medlogics Device Corporation (MDC)
4.48     Medtronic Vascular
4.49     Miami Cardiovascular Innovations
4.50     Micell Technologies
4.51     MicroPort Scientific Corporation
4.52     Minvasys
4.53     MIV Therapeutics
4.54     mNEMOSCIENCE GmbH
4.55     MoBeta, Inc.
4.56     NanoInterventions, LLC
4.57     Neovasc, Inc.
4.58     Nexeon MedSystems, Inc.
4.59     Opto Circuits (India) Ltd.
4.59.1  EuroCor GmbH
4.60     OrbusNeich
4.61     Palmaz Scientific, Inc.
4.62     Picarus NV
4.63     Possis Medical (Bayer)
4.64     Prescient Medical
4.65     Relisys Medical Devices
4.66     REVA Medical
4.67     Sahajanand Medical Technologies
4.68     Stentys SAS
4.69     Terumo
4.70     Translumina
4.71     TriReme Medical
4.72     Tryton Medical
4.73     Vascular Concepts
4.74     VasoTech, Inc.
4.75     X-Cell Medical
4.76     Xtent, Inc. (August 3, 2009:  Xtent shareholders approve plan to dissolve and liquidate company after it is unable to raise the necessary funds to continue its stent development.)

APPENDIX I:  SELECTED CLINICAL TRIALS

ABSORB
ARRIVE II Registry
ARTS
AXXESS PLUS
BASKET
BBC ONE
CARE
COREL
COSTAR
COURAGE
CUSTOM
DEScover Registry
DIRECT
DIVERGE
e-HEALING
EASTER Registry
ENDEAVOR
ETHOS
EuroSTAR
EVENT Registry
FAME
GENESIS
FOCUS
HEALING
HORIZONS-AMI
ISAR, ISAR-TEST-2
LONG DES
NOBLESS
NOBORI
NORDIC
OLYMPIA Registry
PASSION
PREPARE
PROGRESS
RESOLUTE
RESORB
REWARD Registries
SERIES
SIMPLE Registries
SIRIUS, E-SIRIUS, C-SIRIUS
SORT-OUT III
SPIRIT
STEALTH
STEMI
STENT Registry
SVELT
TAXUS
TYPHOON
ZEST-AMI
ZOMAXX
APPENDIX II:  COMPANY DIRECTORY

List of Exhibits

Exhibit ES-1: Types of Cardiovascular Disease and Incidence in the United States, 2006
Exhibit ES-2: Prevalence, Mortality and Hospital Discharges for Cardiovascular Disease Patients in the United States
Exhibit ES-3: Potential Complications Related to Implantation of Cardiovascular Stents
Exhibit ES-4: Types of Coronary Stents and Selected Anti-Restenosis Devices
Exhibit ES-5: Worldwide DES Market by Company, Calendar 4th Quarter, 2008
Exhibit ES-6: Worldwide Market for Coronary Stents, by Type, Revenue Forecast, 2008–2017
Exhibit ES-7: Worldwide Market for Drug-Eluting Coronary Stents, by Region, Revenue Forecast, 2008–2017
Exhibit ES-8: Worldwide Market for Bare Metal Coronary Stents, by Region, Revenue Forecast, 2008–2017
Exhibit ES-9: Worldwide Market for Absorbable Coronary Stents, by Region, Revenue, 2012–2017

Exhibit 1-1: Types of Cardiovascular Disease and Incidence in the United States, 2006
Exhibit 1-2: International Death Rates Per 100,000 Population for Total Cardiovascular Disease and Coronary Heart Disease for the Top 20 Countries
Exhibit 1-3: Prevalence, Mortality and Hospital Discharges for Cardiovascular Disease Patients in the United States
Exhibit 1-4: Drug-Eluting Balloon Catheters
Exhibit 1-5: Estimated Inpatient Cardiovascular Procedures, U.S., 2006 (000)
Exhibit 1-6: Number of Discharges, Coronary Atherosclerosis, U.S.
Exhibit 1-7: National Healthcare Cost and Utilization Project Statistics: Mean Charges and In-Hospital Death Rates for Various Cardiovascular Procedures, U.S.
Exhibit 1-8: Total Number of Cardiac Revascularization Discharges and Mean Charges, U.S., 1993–2006
Exhibit 1-9: Total Number of Discharges for PCI Procedures with Non-Drug-Eluting Stents and Mean Charges, U.S., 2002–2006
Exhibit 1-10: Total Number of Discharges for PCI Procedures with Drug-Eluting Stents and Mean Charges, U.S., 2002–2006
Exhibit 1-11: Total Number of Discharges for PCI Procedures with Non-Drug and Drug-Eluting Stent Discharges and Mean Charges, U.S., 2002–2006

Exhibit 2-1: Competitors in the Market for Bare Metal Stents
Exhibit 2-2: Competitors in the Market for Drug-Eluting Stents
Exhibit 2-3: Competitors in the Market for Bioresorbable Stents
Exhibit 2-4: Competitors in the Market for Novel Stent Technologies

Exhibit 3-1: Worldwide Coronary Stent Market, Unit and Revenue Forecast, 2008-2017
Exhibit 3-2: Worldwide Drug-Eluting Coronary Stent Market, Unit and Revenue Forecast, 2008-2017
Exhibit 3-3: Revenues for Leading Drug-Eluting Stent Market Competitors, Worldwide, 2008
Exhibit 3-4: Worldwide Coronary Bare Metal Stent Market, Unit and Revenue Forecast, 2008-2017
Exhibit 3-5: Worldwide Coronary Absorbable Stent Market, Unit and Revenue Forecast, 2012-2017
Exhibit 3-6: U.S. Market for Coronary Stents, by Type, Revenue Forecast, 2008-2017
Exhibit 3-7: U.S. Coronary Drug-Eluting Stent Market, Unit and Revenue Forecast, 2008-2017
Exhibit 3-8: Revenues for Leading Drug-Eluting Stent Market Competitors, United States, 2008
Exhibit 3-9: U.S. Coronary Bare Metal Stent Market, Unit and Revenue Forecast, 2008-2017
Exhibit 3-10: U.S. Coronary Absorbable Stent Market, Unit and Revenue Forecast, 2013-2017
Exhibit 3-11: European Coronary Stent Market, by Type, Revenue Forecast, 2008-2017
Exhibit 3-12: European Drug-Eluting Stent Market, Unit and Revenue Forecast, 2008-2017
Exhibit 3-13: European Coronary Bare Metal Stent Market, Unit and Revenue Forecast, 2008-2017
Exhibit 3-14: European Coronary Absorbable Stent Market, Unit and Revenue Forecast, 2013-2017
Exhibit 3-15: Asia/Pacific Market Forecasts for Coronary Stents, by Type, Revenue Forecast, 2008-2017
Exhibit 3-16: Asia/Pacific Drug-Eluting Stent Market, Unit and Revenue Forecast, 2008-2017
Exhibit 3-17: Asia/Pacific Coronary Bare Metal Stent Market, Unit and Revenue Forecast, 2008-2017
Exhibit 3-18: Asia/Pacific Coronary Absorbable Stent Market, Unit and Revenue Forecast, 2012-2017
Exhibit 3-19: Rest of World Coronary Stent Market, by Type, Revenue Forecast 2008-2017
Exhibit 3-20: Rest of World Drug-Eluting Stent Market, Unit and Revenue Forecast, 2008-2017
Exhibit 3-21: Rest of World Coronary Bare Metal Stent Market, Unit and Revenue Forecast, 2008-2017
Exhibit 3-22: Rest of World Coronary Absorbable Stent Market, Unit and Revenue Forecast, 2012-2017

Exhibit 4-1: AdvanSource Biomaterials Third Quarter Financial Results ($000s)
Exhibit 4-2: Medtronic Financial Data, Third Quarter 2009 ($millions)
Exhibit 4-3: Medtronic’s Coronary Stent Revenues, FY 2008 & 2009 ($millions)
Exhibit 4-4: Xtent Financial Data, Fourth-Quarter 2008 ($millions)

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Spine Surgery Worldwide 2008-2017: Products, Technologies, Markets and Opportunities

This report details the complete range of products and technologies in spine surgery, including the surgical management of spine disorders, diseases and trauma, with treatments including use of grafts, demineralized bone, fusion, stabilization, disc replacement, nucleus replacement, vertebroplasty, kyphoplasty, imaging, minimally invasive surgical technologies, energy-based therapies and biologics. The report details current clinical and technology developments in the huge and rapidly growing spine surgery technologies worldwide market, with data on products in development and on the market; market size and forecast; competitor market shares; competitor profiles; and market opportunity.

This report is a detailed market and technology assessment and forecast of the products and technologies in the management of diseases and disorders of the spine. The report describes diseases and disorders of the spine, encompassing congenital disorders, inflammatory and infectious diseases; degenerative diseases; herniations, stenoses, myelopathies and other “mechanical” disorders of the spine; spinal trauma; tumors of the spine; and others. The report characterizes the patient populations, their current clinical management, and trends in clinical management as new techniques and technologies are expected to be developed and emerge. The report details the currently available products and technologies, and manufacturer offerings. The report details products and technologies under development and markets for each in spine surgery. The report provides a current and forecast assessment of the worldwide markets for these technologies, with geographic segmentation by U.S. & Canada, European Union (detailing France, United Kingdom, Germany, Italy and Spain), Japan and Rest of World. The report provides emphasis on the market impact of new technologies through the coming decade, profiling nearly 100 active companies in this industry, with comprehensive detail on key companies, providing data on their current products, current market position and products under development.

Table of Contents:

Executive Summary
Non-fusion products
Disc arthroplasty (total disc replacement)
Nuclear arthroplasty
European Union
Asia-Pacific
Rest of World
Selected company-related events
Medtronic
LDR Spine
Synthes Spine
Disc Motion Technologies
Spine Structure
Products and technologies
CMS, carriers reverse decision on artificial discs
Cost effectiveness

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Ablation Technologies Worldwide Market, 2008-2017: Products, Technologies, Markets, Companies and Opportunities

This report is a detailed market and technology assessment and forecast of the products and technologies in the ablation market for treatment of soft tissues via energy-based modalities, including electrosurgery, radiosurgery, gamma knife, brachytherapy, cryogenic therapy, fluidjet therapy (hydrotherapy), microwave ablation, radiofrequency ablation, laser, thermal ablation, and ultrasonic ablation.

The report describes alternative energy-based technologies and the nature of their effect on soft tissue, the underlying basis of the technology, the requisite systems for their use (including capital equipment, devices and disposables), and their strengths and weaknesses for specific clinical applications. The report details current and anticipated target applications and assesses the current and forecast caseload for each energy-based therapeutic considering competition from any and all alternative energy-based or other therapeutics, with current and worldwide market forecasts (2008-2017) segmented by technology type and specific clinical segment. The report provides segmentation of the worldwide ablation market by both ablation technology and region/country: Americas (USA, Canada, Mexico, Brazil), Europe (Germany, United Kingdom, France, Italy, Spain, BeNeLux), Asia/Pacific (Japan, China, India, Australia) and Rest of World. The report details the current and emerging products, technologies and markets for each energy-based therapy. The report profiles over 60 key companies in this industry detailing their current products, current market position and products under development.

Table of Contents:

EXECUTIVE SUMMARY
Overview
Trends and Opportunities
Market Leaders

SECTION 1: ENERGY-BASED THERAPIES BY DISEASE STATE AND TECHNOLOGY
1.1 Cancer
1.1.1 Cryogenic therapy
1.1.2 Microwave therapy
1.1.3 Radiation therapy
1.1.4 Radiofrequency ablation
1.1.5 Stereotactic surgery
1.1.6 Thermal ablation
1.1.7 Laser ablation
1.1.8 Photodynamic therapy
1.1.9 Ultrasonic ablation
1.2 Cardiovascular disease
1.2.1 Angina pectoris
1.2.2 Atrial arrhythmias
1.2.2.1 Laser ablation
1.2.2.2 Cryoablation
1.2.2.3 Electrical cardioversion
1.2.2.4 Microwave ablation
1.2.2.5 RF ablation
1.2.3 Bradycardia
1.2.4 Critical ischaemia
1.2.5 Vascular occlusive disease
1.2.6 Ventricular arrhythmias
1.2.7 Wolf-Parkinson-White Disease
1.3 Elective surgery
1.3.1 Cosmetic surgery
1.3.1.1 Laser hair removal
1.3.1.2 Port wine stains
1.3.1.3 Psoriasis
1.3.1.4 Varicose veins
1.3.2 Ophthalmic surgery
1.3.2.1 Capsulotomy surgery
1.3.2.2 Laser in-situ keratomileusis (LASIK)
1.3.2.2.1 Wave-front guided laser in-situ keratomileusis
1.3.2.3 Laser epithelial keratomileusis (LASEK)
1.4 General surgery
1.4.1 Fecal incontinence
1.4.2 GERD
1.5 Gynecological applications
1.5.1 Hysterectomy
1.5.2 Menorrhagia
1.5.3 Bladder neck suspension
1.5.4 Fibroids
1.6 Urological applications
1.6.1 Urinary tract stones
1.6.2 Benign prostatic hypertrophy
1.6.2.1 TUMT
1.6.2.2 TUNA
1.6.2.3 Vaporization of the prostate (PVP)
1.6.2.4 Water-induced thermotherapy
1.7 Orthopedic applications
1.7.1 Capsular shrinkage
1.7.2 Carpal tunnel syndrome
1.7.3 Chondroplasty
1.7.4 Debridement
1.7.5 Epicondylitis and tendinitis
1.7.6 Inflammatory conditions
1.7.7 Nucleoplasty

Section 2: PRODUCTS AND TECHNOLOGIES
2.1 Cryogenic energy
2.2 Electrical energy
2.2.1 Implantable cardioverter defbibrillators
2.2.2 Resynchronisation systems
2.2.3 Pacing systems
2.2.4 Pain management
2.3 Hydromechanical energy
2.4 Light energy
2.4.1 Cold lasers
2.4.2 Excimer lasers
2.4.3 Photonic ablation
2.4.4 Ultraviolet B lasers
2.5 Microwave energy
2.6 Radiation energy
2.6.1 Brachytherapy
2.6.2 Radiosurgery
2.6.2.1 Cyberknife
2.6.2.2 Gamma knife
2.7 Radiofrequency energy
2.8 Thermal energy
2.9 Ultrasonic energy
2.9.2.1 Shock wave therapy
2.9.2.2 Ultrasonic surgical systems

Section 3: ABLATION TECHNOLOGIES MARKET
3.1 World market overview
3.2 Market segmentation by product type
3.3 Leading companies in global market
3.4 Major national markets
3.4.1 Americas
3.4.1.1 USA
3.4.1.2 Canada
3.4.1.3 Mexico
3.4.1.4 Brazil
3.4.2 Europe
3.4.2.1 Germany
3.4.2.2 United Kingdom
3.4.2.3 France
3.4.2.4 Italy
3.4.2.5 Spain
3.4.2.6 Benelux countries
3.4.3 Asia/Pacific
3.4.3.1 Japan
3.4.3.2 China
3.4.3.3 Australia
3.4.3.4 South Korea
3.4.3.5 India
3.4.4 Rest of world

Section 4: COMPANY PROFILES
4.1 The Industry
4.1.1 Abla-TX
4.1.1.1 Role in Cancer Treatment
4.1.2 Acoustic MedSystems
4.1.3 Accuray
4.1.4 ACMI/Gyrus/Olympus
4.1.5 AFx (Guidant)
4.1.6 Alcon
4.1.7 American Medical Systems
4.1.8 Angiodynamics
4.1.8.1 Financials
4.1.9 ArthroCare Corporation
4.1.10 AtriCure, Inc.
4.1.11 ATS Medical
4.1.11.1 Financial results
4.1.12 Bard EP
4.1.13 Bausch & Lomb (Warburg Pincus)
4.1.14 Baylis Medical Company
4.1.15 Biosense Webster
4.1.16 Biotronik Inc.
4.1.17 Biowave Corp
4.1.18 Boston Scientific Corp
4.1.18.1 Blazer Cardiac Ablation Catheters
4.1.18.2 Chilli Cooled Ablation Catheters
4.1.18.3 Steerocath-T Cardiac Ablation Catheter
4.1.18.4 Maestro
4.1.18.5 RF 3000® Radiofrequency Ablation System
4.1.18.6 Confient Implantable Cardioverter Defibrillator (ICD)
4.1.18.7 Financials
4.1.19 BSD Medical Corp.
4.1.19.1 MicroThermX-100 Microwave Ablation Systems
4.1.19.2 BSD500 Hyperthermia Systems
4.1.19.3 BSD2000 Hyperthermia Systems
4.1.20 Candela Corp.
4.1.21 Cardima Inc
4.1.22 CardioGenesis Corp
4.1.23 Celon AG
4.1.23.1 Surgery/Radiology
4.1.23.2 Phlebology
4.1.24 Celsion Corp.
4.1.25 ConMed Corp.
4.1.26 Covidien Ltd.
4.1.26.1 Vessel Sealing
4.1.26.2 Electrosurgery
4.1.26.3 Financial Results for fiscal 2007 and 2006
4.1.27 CryoCath
4.1.28 CryoCor, Inc.
4.1.29 CSA Medical Inc.
4.1.30 Cytyc Corp.
4.1.31 Dornier MedTech
4.1.31.1 Compact Delta II
4.1.31.2 Compact Delta II UIMS
4.1.31.3 Compact Sigma
4.1.31.4 Lithotripter S II
4.1.31.5 Medilas D MultiBeam
4.1.31.6 Medilas D FlexiPulse
4.1.31.7 Medilas H 20
4.1.32 EDAP TMS S.A.
4.1.32.1 Financial Update
4.1.33 Elekta
4.1.33.1 Leksell Gamma Knife 4
4.1.33.2 Leksell Gamma Knife 4C
4.1.33.3 Leksell Gamma Knife Perfexion
4.1.34 Endocare (merged with Galil Medical)
4.1.35 Erbe
4.1.35.1 Electrosurgery
4.1.35.2 Water Jet Surgery
4.1.35.3 Cryosurgery
4.1.36 Ethicon Endo-Surgery Inc.
4.1.37 Galil Medical (merged with Endocare)
4.1.38 Getinge Group
4.1.38.1 Cardiac Surgery
4.1.38.2 Vascular Surgery
4.1.39 HealthTronics Surgical Services
4.1.39.1 Medical Products
4.1.39.2 Urology Services
4.1.40 Medtronic
4.1.40.1 Cardiac Rhythm Disease Management (CRDM)
4.1.40.2 Bradycardia
4.1.40.3 Tachyarrhythmia
4.1.40.4 Ablation Catheters
4.1.41 MedWaves Inc.
4.1.42 Mirabilis Medica
4.1.43 Misonix Inc.
4.1.43.1 Sonablate
4.1.44 NeuWave Medical Inc.
4.1.45 Olympus Medical
4.1.46 OmniSonics Medical Technologies Inc. — filed for Chapter 7 bankruptcy in March 2009
4.1.47 PhotoMedex Inc.
4.1.48 PhotoTherapeutics Inc.
4.1.49 PhotoThera Inc.
4.1.50 RFA Medical Inc.
4.1.51 Smith & Nephew
4.1.51.1 Financial Results
4.1.52 Spectranetics
4.1.53 St Jude Medical Inc.
4.1.53.1 Products for Cardiac Rhythm Management
4.1.53.2 Atrial Fibrillation
4.1.53.3 Advanced Neuromodulation Systems
4.1.54 Starion Instruments
4.1.55 Stereotaxis Inc.
4.1.55.1 Stereotaxis Magnetic Navigation System
4.1.56 Theragenics Corporation
4.1.57 Urologix Inc
4.1.57.1 Targis System
4.1.58 USHIFU
4.1.59 Varian Medical Systems Inc.
4.1.59.1 RapidArc
4.1.59.2 Dynamic Targeting Image-Guided Radiation Therapy (IGRT)
4.1.59.3 SmartBeam IMRT
4.1.59.4 Dynamic Adaptive Radiotherapy (DART)
4.1.59.5 IGBT - Image-Guided Brachytherapy
4.1.59.6 Varian Proton Therapy System
4.1.60 VNUS Medical Technologies, Inc.
4.1.60.1 ClosureFAST System
4.1.60.2 Model RFG2 Advanced Radiofrequency Generator
4.1.60.3 Quarterly Financials
APPENDIX: COMPANY DETAILS

List of Exhibits

Exhibit ES-1: Overview of the Global Ablation and Other Energy-Based Therapies Market by Modality
Exhibit ES-2: Growth of the Worldwide Ablation and Other Energy-Based Therapies Market by Modality
Exhibit ES-3: Worldwide Ablation and Other Energy-Based Therapies Market by Clinical Application
Exhibit ES-4: Market Leaders in Energy-Based Therapies

Exhibit 1-1: Energy-Based Treatment Options for Prostate Cancer
Exhibit 1-2: Energy-Based Therapies for Cardiovascular Diseases
Exhibit 1-3: Energy-based Therapies for Atrial Arrhythmias
Exhibit 1-4: Ventricular Arrhythmia Therapies
Exhibit 1-5: Energy-based Implants for Ventricular Arrhythmias
Exhibit 1-6: Cosmetic Lasers
Exhibit 1-7: Traditional LAVH vs PK LVAH
Exhibit 1-8: Orthopedic Application of Electrosurgical Devices
Exhibit 1-9: Collagen Types
Exhibit 1-10: Chondroplasty Systems’ Zone of Thermal Damage

Exhibit 2-1: Energy-Based Technologies
Exhibit 2-2: Cryogenic-Energy Ablation Products
Exhibit 2-3: Electrical-Energy Ablation Products
Exhibit 2-4: Hydromechanical Ablation Products
Exhibit 2-5: Light-Energy Ablation Products
Exhibit 2-6: Microwave Ablation Products
Exhibit 2-7: Radiation-Energy Ablation Products
Exhibit 2-8: Radioactive Seed Products for Brachytherapy
Exhibit 2-9: Radiofrequency (RF) Ablation Products
Exhibit 2-10: Thermal-Energy Ablation Products
Exhibit 2-11: Ultrasound Ablation Products
Exhibit 2-12: High Growth Applications of Ultrasonic Surgical Systems

Exhibit 3-1: World Medical Device Market, by Region, 2008
Exhibit 3-2: World Energy-based Device Market by Product Category, 2007
Exhibit 3-3: Overview of the Energy-Based Therapies Market by Clinical Application
Exhibit 3-4: Arrhythmias Treated with Ablation Therapy
Exhibit 3-5: 25-Year Changes in National Mortality Rates Due to Ischaemic Heart Disease
Exhibit 3-6: Cardiac Angioplasty Procedures Per 100,000 Population, By Country in 2000
Exhibit 3-7: Cardiac Dysrhythmias and Related Conditions
Exhibit 3-8: Solid cancers: Ablation Market Potential
Exhibit 3-9: World Age-Standardize Cancer Incidence per 100, 000 Population (All Ages), by Cancer Type
Exhibit 3-10: Global Energy-based Therapies Market, by Product Category
Exhibit 3-11: World Energy-based Device Market by Product Category, 2007 and 2017
Exhibit 3-12: Ablation and Energy-based Therapeutic Companies by Product Area, Indication and Market Shares, Worldwide, 2008
Exhibit 3-13: Ablation Market Revenues ($millions), Americas, by Country, 2007-2017
Exhibit 3-14: Ablation Market Revenues ($000s) US, by Product Segment, 2007-2017
Exhibit 3-15: Ablation Market Revenues ($000s), Canada, by Product Segment, 2007-2017
Exhibit 3-16: Ablation Market Revenues ($000s), Brazil, by Product Segment, 2007-2017
Exhibit 3-17: Ablation Market Revenues ($000s), Mexico, by Product Segment, 2007-2017
Exhibit 3-18: Ablation Market Revenues ($millions), Europe, by Country, 2007-2017
Exhibit 3-19: Ablation Market Revenues ($000s), Germany, by Product Segment, 2007-2017
Exhibit 3-20: Ablation Market Revenues ($000s), United Kingdom, by Product Segment, 2007-2017
Exhibit 3-21: Ablation Market Revenues ($000s), France, by Product Segment, 2007-2017
Exhibit 3-22: Ablation Market Revenues ($000s), Italy, by Product Segment, 2007-2017
Exhibit 3-23: Ablation Market Revenues ($000s), Spain, by Product Segment, 2007-2017
Exhibit 3-24: Ablation Market Revenues ($000s), BeNeLux, by Product Segment, 2007-2017
Exhibit 3-25: Ablation Market Revenues ($millions), Asia/Pacific, by Country, 2007-2017
Exhibit 3-26: Ablation Market Revenues ($000s), Japan, by Product Segment, 2007-2017
Exhibit 3-27: Ablation Market Revenues ($000s), China, by Product Segment, 2007-2017
Exhibit 3-28: Ablation Market Revenues ($000s), India, by Product Segment, 2007-2017
Exhibit 3-29: Ablation Market Revenues ($000s), Australia, by Product Segment, 2007-2017
Exhibit 3-30: Ablation Market Revenues ($millions), Rest of World, 2007-2017
Exhibit 3-31: Ablation Market Revenues ($000s), Rest of World, by Product Segment, 2007-2017

Exhibit 4-1: M&A Activity Among Energy-based Companies
Exhibit 4-2: AngioDynamics Financial Figures for Fiscal 2007 and 2006
Exhibit 4-3: ATS Financial Results for Q2 2008 and 2007
Exhibit 4-4: Boston Scientific Financials, Three Months Ended June 30, 2007 & 2008
Exhibit 4-5: CardioGenesis Financial Data, 2006 &2007
Exhibit 4-6: Covidien Ltd Financial Results, 2006 & 2007
Exhibit 4-7: Covidien Medical Device sales by Product Group
Exhibit 4-8: EDAP TMS Financial Results, 1st Quarter 2008 (to March 31st)
Exhibit 4-9: Endocare Quarterly Results, 2007 & 2008
Exhibit 4-10: Medtronic Revenues, 2007
Exhibit 4-11: Six-month Financial Data for Smith & Nephew, 2007 & 2008
Exhibit 4-12: TheraGenics Financial Results, Fourth Quarter 2007 and Full Year
Exhibit 4-13: Varian Medical Systems, Financial Summary, 2005-2007

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